SCHEMBL4201225

SCHEMBL4201225

C[Si](C)(CCCCS)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 9/20 0.39
HDAC4 P56524 9/20 0.39
HDAC1 Q13547 9/20 0.39
HDAC2 Q92769 9/20 0.39
HDAC10 Q969S8 9/20 0.39
HDAC11 Q96DB2 9/20 0.39
HDAC8 Q9BY41 9/20 0.39
HDAC6 Q9UBN7 9/20 0.39
HDAC5 Q9UQL6 9/20 0.39
HDAC7 Q8WUI4 8/20 0.39
HDAC9 Q9UKV0 8/20 0.39
MGAM O43451 2/20 0.39
MAPT P10636 1/20 0.38
NR1H2 P55055 4/20 0.35
NR1H3 Q13133 4/20 0.35
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
IDO1 P14902 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4346243 0.94 MGAM (0.40) HDAC3HDAC4HDAC1HDAC2HDAC10
SCHEMBL18084487 0.89 MGAM (0.44) HDAC3HDAC4HDAC1HDAC2HDAC10
SCHEMBL9217667 0.79 MAPT (0.47) MGAMMAPTNR1H2NR1H3ESR1
SCHEMBL11356400 0.79 NR1H2 (0.50) MGAMMAPTNR1H2NR1H3ESR1
SCHEMBL20482223 0.79 NR1H2 (0.46) MGAMNR1H2NR1H3
SCHEMBL7536048 0.79 NR1H2 (0.46) MGAMNR1H2NR1H3
SCHEMBL8970648 0.79 MGAM (0.39) HDAC3HDAC4HDAC1HDAC2HDAC10
SCHEMBL3235109 0.79 MGAM (0.39) HDAC3HDAC4HDAC1HDAC2HDAC10
SCHEMBL2965525 0.79 MGAM (0.39) HDAC3HDAC4HDAC1HDAC2HDAC10
SCHEMBL28899778 0.79 NR1H2 (0.46) MGAMNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6507049-B1 Encapsulants for solid state devices GENERAL ELECTRIC COMPANY 2003-01-14 US claimed
WO-2002019440-A1 ENCAPSULANTS FOR SOLID STATE DEVICES GENERAL ELECTRIC COMPANY (US) 2002-03-07 WO claimed
US-5145889-A For light-emitting diodes KABUSHIKI KAISHA TOSHIBA (JP) 1992-09-08 US claimed
US-20090121251-A1 Siloxane-hydantoin copolymer, optoelectronic device encapsulated therewith and method LUMINATION LLC 2009-05-14 US disclosed
US-20080160317-A1 Optoelectronic device GELCORE LLC 2008-07-03 US disclosed
US-20080001140-A1 Optoelectronic device GELCORE LLC 2008-01-03 US disclosed
US-20070299162-A1 Light emitting semiconductor and encapsulant is made from nano-functionalized zirconia; silicone epoxy, epoxy isocyanurate and succinic anhydride, dodecenylsuccinic anhydride, phthalic anhydride curing agent; ancillary curing catalyst, cure modifier, coupling agent, UV, thermal stabilizer GELCORE LLC 2007-12-27 US disclosed
US-20070295983-A1 Optoelectronic device GELCORE LLC 2007-12-27 US disclosed
US-20070295956-A1 Optoelectronic device GELCORE LLC 2007-12-27 US disclosed
EP-1408087-B1 Epoxy-polysiloxane resin compositions, solid state devices encapsulated therewith and method GEN ELECTRIC (US) 2007-10-10 EP disclosed
US-7144763-B2 light emitting diode; curable silicone with pendant epoxy groups, a hydroxyl-containing compound or silicone, anhydride curing agent, ancillary curing catalyst; radiation transparent, UV stability, clear; packaging GENERAL ELECTRIC COMPANY (US) 2006-12-05 US disclosed
US-6617400-B2 Free of halogen, and contains at least one cure modifier, and, optionally at least one ancillary curing catalyst; for encapsulating a solid state device GENERAL ELECTRIC COMPANY 2003-09-09 US disclosed
US-6617401-B2 Free of halogen, and contains at least one cure modifier, and, optionally at least one ancillary curing catalyst; for encapsulating a solid state device GENERAL ELECTRIC COMPANY 2003-09-09 US disclosed
US-20030071368-A1 Epoxy resin compositions, solid state devices encapsulated therewith and method GENERAL ELECTRIC COMPANY 2003-04-17 US disclosed
US-20030071367-A1 Epoxy resin compositions, solid state devices encapsulated therewith and method GENERAL ELECTRIC COMPANY 2003-04-17 US disclosed
US-20030071366-A1 For encapsulating a solid state device, such as a light emitting diode GENERAL ELECTRIC COMPANY 2003-04-17 US disclosed
EP-1285938-A1 Epoxy resin encapsulation compositions GENERAL ELECTRIC COMPANY (US) 2003-02-26 EP disclosed
EP-1285939-A1 Epoxy resin compositions and solid state devices encapsulated therewith GENERAL ELECTRIC COMPANY (US) 2003-02-26 EP disclosed
US-6507049-B1 Encapsulants for solid state devices GENERAL ELECTRIC COMPANY 2003-01-14 US disclosed
US-5145889-A For light-emitting diodes KABUSHIKI KAISHA TOSHIBA (JP) 1992-09-08 US disclosed