Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 11/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017751 | 0.86 | MAPK10 (0.64) | MAPK10MAPK9MAPK8TSHRPIK3CA | |
| SCHEMBL2884385 | 0.81 | MAPK10 (0.70) | MAPK10MAPK9MAPK8TSHR | |
| SCHEMBL4192590 | 0.80 | MAPK10 (0.44) | MAPK10MAPK9MAPK8 | |
| SCHEMBL4188154 | 0.77 | MAPK10 (0.44) | MAPK10MAPK9MAPK8 | |
| SCHEMBL7706938 | 0.76 | KMT2A (0.37) | — | |
| SCHEMBL5976514 | 0.75 | MAPK10 (0.43) | MAPK10MAPK9MAPK8 | |
| SCHEMBL7704531 | 0.74 | MAPK10 (0.47) | MAPK10MAPK9MAPK8 | |
| SCHEMBL4968704 | 0.74 | MAPK10 (0.49) | MAPK10MAPK9MAPK8 | |
| SCHEMBL2881183 | 0.73 | MAPK10 (0.76) | MAPK10MAPK9MAPK8PIK3CA | |
| SCHEMBL5596240 | 0.72 | MAPK10 (0.78) | MAPK10MAPK9MAPK8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |