Sugi Predict

Sugi Predict / Compounds / SCHEMBL420239

SCHEMBL420239

SCHEMBL420239

O=C1CN(C(=O)c2cc(-c3cccc(Cl)c3)c(-c3ccc(F)c(Cl)c3)o2)CN1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 2/20 0.37
▸ RPA1 P27694 1/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ CREBBP Q92793 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ CHRM1 P11229 6/20 0.33
▸ BRAF P15056 3/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ TDP2 O95551 1/20 0.33
▸ PGR P06401 1/20 0.33
▸ CHRM3 P20309 3/20 0.33
▸ ERCC1 P07992 1/20 0.33
▸ ERCC4 Q92889 1/20 0.33
▸ CHRM2 P08172 1/20 0.33
▸ CHRM4 P08173 1/20 0.33
▸ CHRM5 P08912 1/20 0.33
▸ P2RX7 Q99572 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10102797 0.92 PDE4B (0.41) PDE4BALDH1A1MAPTBRAFNPC1
SCHEMBL417650 0.91 HSP90AA1 (0.40) PDE4BCHRM1BRAFRAB9AP2RX7
SCHEMBL2510578 0.90 PDE4B (0.38) PDE4BALDH1A1MAPTCHRM1NPC1
SCHEMBL419511 0.89 RPA1 (0.35) RPA1BRAFNPC1RAB9ATDP2
SCHEMBL417480 0.89 PDE4B (0.38) PDE4BALDH1A1MAPTCHRM1NPC1
SCHEMBL415848 0.88 KDM4E (0.36) PDE4BALDH1A1MAPTCHRM1BRAF
SCHEMBL418259 0.88 PDE4B (0.37) PDE4BALDH1A1MAPTCHRM1NPC1
SCHEMBL416921 0.84 PDE4B (0.40) PDE4BCHRM1BRAFRAB9ACHRM3
SCHEMBL420516 0.84 MAOB (0.45) PDE4BMAPT
SCHEMBL419740 0.83 PGR (0.34) RPA1BRAFPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376479-B1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO KG (DE) 2016-03-02 — — EP disclosed
EP-2376479-B1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO KG (DE) 2016-03-02 — — EP disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
WO-2010075957-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AADAC, DDC, TPMT PDE4B 1900/4885RPA1 4663/4885BRD4 121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.