SCHEMBL4203473

SCHEMBL4203473

CC(CO)Cc1cc(F)c(Br)cc1F

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.41
CYP1A2 P05177 2/20 0.35
ADRB2 P07550 3/20 0.35
ALOX15 P16050 1/20 0.34
ALOX12 P18054 1/20 0.34
KDM1A O60341 4/20 0.33
KCNH2 Q12809 2/20 0.33
KDM1B Q8NB78 2/20 0.33
NR3C1 P04150 1/20 0.31
AAK1 Q2M2I8 1/20 0.31
TRPA1 O75762 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17069267 0.81 DPP4 (0.46) DPP4ALOX15ALOX12KDM1AKCNH2
SCHEMBL2434491 0.77 PYCR1 (0.42) KDM1A
SCHEMBL15526439 0.77 DPP4 (0.43) DPP4TRPA1
SCHEMBL3904974 0.76 IDO1 (0.43) DPP4TRPA1
SCHEMBL21777383 0.75 HPGD (0.36) ADRB2ALOX15ALOX12TRPA1
SCHEMBL21787333 0.75 HPGD (0.36) ADRB2ALOX15ALOX12TRPA1
SCHEMBL856379 0.74 KDM1A (0.39) CYP1A2KDM1AKCNH2KDM1BAAK1
SCHEMBL12995545 0.72 DPP4 (0.35) DPP4CYP1A2KDM1AKCNH2KDM1B
SCHEMBL377065 0.72 KDM1A (0.41) DPP4KDM1AKCNH2KDM1B
SCHEMBL29545980 0.72 KDM1A (0.41) DPP4KDM1AKCNH2KDM1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2032552-B1 Mesogenic compounds, liquid crystal medium and liquid crystal display MERCK PATENT GMBH (DE) 2016-02-24 EP disclosed
EP-2032552-B1 Mesogenic compounds, liquid crystal medium and liquid crystal display MERCK PATENT GMBH (DE) 2016-02-24 EP disclosed
EP-2032552-A1 MESOGENIC COMPOUNDS, LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DISPLAY Merck Patent GmbH (DE) 2009-03-11 EP disclosed
WO-2007147516-A1 MESOGENIC COMPOUNDS, LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2007-12-27 WO disclosed
WO-2007147516-A1 MESOGENIC COMPOUNDS, LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2007-12-27 WO disclosed