SCHEMBL420349

SCHEMBL420349

CCCCC[CH]NC(=O)C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.52
FAAH O00519 12/20 0.47
CES1 P23141 7/20 0.47
PLA2G4A P47712 2/20 0.45
ALDH1A1 P00352 1/20 0.45
PLA2G4B P0C869 1/20 0.45
MAPT P10636 1/20 0.45
BLM P54132 1/20 0.45
MGLL Q99685 1/20 0.45
PLA2G4C Q9UP65 1/20 0.45
CES2 O00748 5/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
KMT2A Q03164 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7708913 0.94 EPHX1 (0.48) EPHX1FAAHCES1PLA2G4AALDH1A1
SCHEMBL1000784 0.86 EPHX1 (0.42) EPHX1FAAHCES1PLA2G4AALDH1A1
SCHEMBL1556843 0.82 CNR1 (0.39) MAPTBLMCYP1A2HSD17B10
SCHEMBL1556426 0.79 EP300 (0.42) FAAHMAPTBLMMEN1CYP1A2
SCHEMBL7716898 0.79 EPHX1 (0.42) EPHX1FAAHCES1ALDH1A1MAPT
SCHEMBL10893304 0.78 EP300 (0.45) FAAHMAPTBLMMEN1CYP1A2
SCHEMBL10886696 0.78 EP300 (0.45) FAAHMAPTBLMMEN1CYP1A2
SCHEMBL10531391 0.78 EP300 (0.45) FAAHMAPTBLMMEN1CYP1A2
SCHEMBL1555372 0.76 TSHR (0.41) EPHX1BLMCYP1A2HSD17B10
SCHEMBL7045878 0.74 EPHX1 (0.58) EPHX1FAAHCES1PLA2G4AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2178499-B1 MATERIALS AND METHODS FOR DELIVERING COMPOSITIONS TO SELECTED TISSUES UNIV CALIFORNIA (US) 2023-11-22 EP disclosed
US-11241380-B2 Porous photonic crystals for drug delivery to the eye THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-02-08 US disclosed
US-20220000768-A9 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-01-06 US disclosed
EP-3773730-A1 DRUG DELIVERY FORMULATIONS The Regents of The University of California (US) 2021-02-17 EP disclosed
US-20210000744-A1 DRUG DELIVERY FORMULATIONS UNIV CALIFORNIA (US) 2021-01-07 US disclosed
WO-2019191132-A1 DRUG DELIVERY FORMULATIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-03 WO disclosed
US-20190194358-A1 Synthetic Antibodies ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-06-27 US disclosed
EP-3381446-A1 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE The Regents of The University of California (US) 2018-10-03 EP disclosed
US-9937129-B2 Materials and methods for delivering compositions to selected tissues THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-04-10 US disclosed
US-20180055765-A1 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-03-01 US disclosed
EP-1212339-B1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS INC (US) 2008-12-31 EP disclosed
WO-2008048970-A2 SYNTHETIC ANTIBODIES THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2008-04-24 WO disclosed
EP-1817003-A2 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE The Regents of the University of California (US) 2007-08-15 EP disclosed
WO-2006050221-A2 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-05-11 WO disclosed
EP-1212339-A4 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS INC (US) 2002-09-18 EP disclosed
EP-1212339-A1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 2002-06-12 EP disclosed
US-6369101-B1 Therapeutic method to treat herpes virus infection REGENTS OF THE UNIVERSITY OF MINNESOTA 2002-04-09 US disclosed
WO-2001014400-A1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 2001-03-01 WO disclosed
US-6147200-A NUCLEOSIDES FOR SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES HAVING INCREASED NUCLEASE RESISTANCE AND BETTER BINDING AFFINITY; DIAGNOSIS; ANTISENSE THERAPY ISIS PHARMACEUTICALS, INC. (US) 2000-11-14 US disclosed
WO-1998034603-A1 USE OF BETULIN AND ANALOGS THEREOF TO TREAT HERPESVIRUS INFECTION REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1998-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210000744-A1 DRUG DELIVERY FORMULATIONS PGR, FKBP1A, LPXN EPHX1 4087/4885FAAH 3945/4885CES1 3372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.