⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419742 | 0.76 | — | — | |
| SCHEMBL979771 | 0.76 | — | — | |
| SCHEMBL7303886 | 0.74 | CA1 (0.35) | — | |
| SCHEMBL18845026 | 0.73 | — | — | |
| SCHEMBL9423576 | 0.71 | — | — | |
| SCHEMBL7343487 | 0.70 | CA1 (0.36) | — | |
| SCHEMBL981029 | 0.70 | CALM1 (0.42) | — | |
| SCHEMBL21556785 | 0.69 | CA1 (0.39) | — | |
| SCHEMBL17967787 | 0.69 | HIF1A (0.50) | — | |
| SCHEMBL7343489 | 0.69 | CA1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776509-B | N-substituted imidazole formate derivative and application thereof | 成都麻沸散医药科技有限公司 | 2023-07-07 | — | — | CN | disclosed |
| EP-2935278-B1 | TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL | NOVARTIS AG (CH) | 2017-03-15 | — | — | EP | disclosed |
| US-9359381-B2 | Tricyclic compounds for inhibiting the CFTR channel | NOVARTIS AG (CH) | 2016-06-07 | — | — | US | disclosed |
| US-9359381-B2 | Tricyclic compounds for inhibiting the CFTR channel | NOVARTIS AG (CH) | 2016-06-07 | — | — | US | disclosed |
| US-9359381-B2 | Tricyclic compounds for inhibiting the CFTR channel | NOVARTIS AG (CH) | 2016-06-07 | — | — | US | disclosed |
| CN-105143230-A | Tricyclic compounds for inhibiting the CFTR channel | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |
| US-20150336986-A1 | TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL | NOVARTIS AG (CH) | 2015-11-26 | — | — | US | disclosed |
| US-20150336986-A1 | TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL | NOVARTIS AG (CH) | 2015-11-26 | — | — | US | disclosed |
| US-20150336986-A1 | TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL | NOVARTIS AG (CH) | 2015-11-26 | — | — | US | disclosed |
| EP-2935278-A1 | TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL | Novartis AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| US-20060270853-A1 | Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one | HOFFMANN-LA ROCHE INC. | 2006-11-30 | — | — | US | disclosed |
| US-20060270853-A1 | Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one | HOFFMANN-LA ROCHE INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2003051857-A2 | FURANONE SYNTHESIS | MERCK PATENT GMBH (DE) | 2003-06-26 | — | — | WO | disclosed |
| US-6451785-B1 | SUBSTITUTED 3-(TRIPHENYLMETHYLAMINO)AZETIDIN-2-ONE; COA-INDEPENDENT TRANSACYLASE (COA-IT) INHIBITOR; COADMINISTERED WITH EDELFOSINE (ET-18-OCH3) OR OTHER ALKYL-LYSOPHOSPHOLIPID ANALOG | SMITHKLINE BEECHAM CORPORATION | 2002-09-17 | — | — | US | disclosed |
| US-20020082250-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2002-06-27 | — | — | US | disclosed |
| EP-1011663-A1 | BETA-LACTAM INHIBITORS OF CoA-IT | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0982991-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050032-A9 | BETA-LACTAM INHIBITORS OF CoA-IT | SMITHKLINE BEECHAM CORP (US) | 1999-03-25 | — | — | WO | disclosed |
| WO-1998049897-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998050032-A1 | BETA-LACTAM INHIBITORS OF CoA-IT | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |