Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3SLC6A2
The experimentally established mechanism targets of Racephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 1.00 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | RGS12 | O14924 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | GNAI1 | P63096 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephedrine SCHEMBL2633794 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Ephedrine SCHEMBL4785 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Ephedrine SCHEMBL30411556 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL8098202 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL11906521 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL4786 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Ephedrine SCHEMBL4731265 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL12573578 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL4369 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Pseudoephedrine SCHEMBL4368 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 771 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119214988-A | Nasal administration preparation for treating rhinitis, preparation method and application | 博济医药科技股份有限公司 | 2024-12-31 | — | — | CN | claimed |
| CN-105473545-A | Dihydroxyphenyl neurotransmitter compounds, compositions, and methods | AUSPEX PHARMACEUTICALS INC | 2016-04-06 | — | — | CN | claimed |
| CN-103249725-B | The method of synthesis of cyclic carbamate | BRISTOL-MYERS SQUIBB CO. (US) | 2016-01-20 | — | — | CN | claimed |
| CN-104745586-A | Cocaine aptamer, detection kit and application thereof | SHANGHAI CRIMINAL SCIENCE TECHNOLOGY RES INST | 2015-07-01 | — | — | CN | claimed |
| CN-104745585-A | Methamphetamine aptamer, detection kit and application thereof | SHANGHAI CRIMINAL SCIENCE TECHNOLOGY RES INST | 2015-07-01 | — | — | CN | claimed |
| CN-102617528-B | Tricyclic acetate compound with optical activity, and preparation method and application thereof | UNIV SICHUAN | 2015-04-29 | — | — | CN | claimed |
| CN-104177448-A | Processes For Making Lactose Utilizing Pre-Classification Techniques And Pharmaceutical Formulations Formed Therefrom | GLAXO GROUP LTD | 2014-12-03 | — | — | CN | claimed |
| CN-101654445-B | Compound for preparing ramelteon, preparation method and application thereof | UNIV SICHUAN | 2014-07-23 | — | — | CN | claimed |
| CN-103923081-A | Compound, preparation method and application thereof | WUHAN GUANGGU RENFU BIOLOG PHARMACEUTICAL CO LTD | 2014-07-16 | — | — | CN | claimed |
| CN-103833915-A | Molecular imprinting polymer nanoparticles for pure biological sample, and preparation method thereof | UNIV NANKAI | 2014-06-04 | — | — | CN | claimed |
| EP-0480934-B1 | A SLIMMING PHARMACEUTICAL COMPOSITION | NYCOMED DAK AS (DK) | 1994-06-29 | — | — | EP | claimed |
| WO-1993015066-A1 | BENZOPYRAN AND RELATED LTB4 ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | claimed |
| CN-1074681-A | Chromene and relevant leukotriene B 4Antagonist | PFIZER (US) | 1993-07-28 | — | — | CN | claimed |
| CN-1010587-B | Process for preparing salts | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1990-11-28 | — | — | CN | claimed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | claimed |
| EP-0094776-B1 | NOVEL PROCESS FOR THE PREPARATION OF BIOTIN | PFIZER INC. (US) | 1988-06-22 | — | — | EP | claimed |
| CN-86103741-A | New salt preparation method | — | 1987-02-18 | — | — | CN | claimed |
| US-4468516-A | Process for the preparation of biotin | PFIZER INC. (US) | 1984-08-28 | — | — | US | claimed |
| US-4328173-A | Resolution of D,L-cis and D,L-trans 2,2-dimethyl-3-(2,2-dihalovinyl)-cyclopropane-1-carboxylic acids and salts thereof | ROUSSEL UCLAF (FR) | 1982-05-04 | — | — | US | claimed |
| US-3946046-A | Resolution of prostaglandin intermediates by means of oxazolidines | THE UPJOHN COMPANY (US) | 1976-03-23 | — | — | US | claimed |