Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Ephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 1.00 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | RGS12 | O14924 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | GNAI1 | P63096 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephedrine SCHEMBL2633794 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Ephedrine SCHEMBL30411556 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL8098202 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL11906521 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL4786 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Ephedrine SCHEMBL4731265 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL12573578 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL4369 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Pseudoephedrine SCHEMBL4368 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 | |
| Racephedrine SCHEMBL420779 | 1.00 | CYP2D6 (1.00) | CYP2D6ADRA2CCYP3A4CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 48238 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122087518-A | Method for classifying anesthetic drugs by using neural network | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075559-A | Portulaca oleracea extract based on bioaffinity ultrafiltration screening and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122056926-A | Probiotic composition containing melatonin and application of composition in sleep | 南京北极光生物科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12631647-B2 | Lock and key templation of molecularly imprinted polymer for small molecule recognition | Genesee Valley Innovations, LLC (US) | 2026-05-19 | — | — | US | claimed |
| CN-114008013-B | Treatment of CNS disorders with sleep disorders | 哥本哈根大学 | 2026-05-15 | — | — | CN | claimed |
| WO-2026098386-A1 | AGROCHEMICAL ADHESION SYNERGIST BASED ON PLANT-DERIVED PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 陕西师范大学 | 2026-05-15 | — | — | WO | claimed |
| CN-122005688-A | Chinese herbal compound preparation for enhancing transdermal absorption and antibacterial activity and preparation and application thereof | 广西白云山盈康药业有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-4151360-A | Optically active amine salts | HOFFMANN-LA ROCHE INC. (US) | 1979-04-24 | — | — | US | claimed |
| US-4133826-A | REACTION OF OPTICALLY ACTIVE OR RACEMIC MIXTURE OF ESTERS WITH BASE | ROUSSEL UCLAF (FR) | 1979-01-09 | — | — | US | claimed |
| US-RE29875-E | THEOPHYLLINE SOLUBILIZED BY GLYCERYL GUAIACOLATE, POTASSIUM GUAIACOL SULFONATE OR GUAIACOL | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | claimed |
| US-4066747-A | Polymeric orthoesters housing beneficial drug for controlled release therefrom | ALZA CORPORATION (US) | 1978-01-03 | — | — | US | claimed |
| US-4036227-A | Osmotic releasing device having a plurality of release rate patterns | ALZA CORPORATION (US) | 1977-07-19 | — | — | US | claimed |
| US-4034087-A | TREATING PROLIFERATIVE SKIN DISEASES WITH 4-BENZYL-2-IMIDAZOLIDONES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1977-07-05 | — | — | US | claimed |
| US-4005146-A | REACTION WITH SUCCINIC ACID AND EPHEDRINE | ROUSSEL-UCLAF (FR) | 1977-01-25 | — | — | US | claimed |
| US-3977404-A | OSMOTIC DEVICE HAVING MICROPOROUS RESERVOIR | ALZA CORPORATION (US) | 1976-08-31 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |
| US-3946046-A | Resolution of prostaglandin intermediates by means of oxazolidines | THE UPJOHN COMPANY (US) | 1976-03-23 | — | — | US | claimed |