Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4209323 | 1.00 | CTSB (0.46) | CTSBCTSSSCN5ASCN9A | |
| SCHEMBL4207219 | 0.93 | CTSB (0.47) | CTSBCTSSSCN5ASCN9A | |
| SCHEMBL4207206 | 0.93 | CTSB (0.47) | CTSBCTSSSCN5ASCN9A | |
| SCHEMBL13929752 | 0.91 | CTSB (0.47) | CTSBCTSS | |
| SCHEMBL8087645 | 0.91 | CTSB (0.45) | CTSBCTSS | |
| SCHEMBL4187251 | 0.89 | CTSB (0.37) | CTSBCTSS | |
| SCHEMBL13929753 | 0.89 | CTSB (0.46) | CTSBCTSS | |
| SCHEMBL4187261 | 0.88 | CTSB (0.36) | CTSBCTSS | |
| SCHEMBL4221020 | 0.85 | CTSB (0.33) | CTSB | |
| SCHEMBL4180941 | 0.85 | CTSB (0.33) | CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090047244-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS I | IDENIX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047244-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS I | SERPINB1, SPINT2, PRSS1 | CTSB 57/4885CTSS 45/4885SCN5A 3841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.