Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levmetamfetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.95 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.95 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL9114797 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL1608168 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42098 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42100 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL9114800 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL13747483 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL15094315 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL20211416 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42615 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL727412 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3135 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122055143-A | Solid compositions containing bromhexine | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| US-12436136-B2 | Device for the detection of conditions indicative of illicit drug production | P ALERT LIMITED (NZ) | 2025-10-07 | — | — | US | claimed |
| US-12257283-B2 | Methods and compositions for use of a chemokine receptor antagonist peptide to treat addiction, substance abuse disorders or symptoms thereof | CREATIVE BIO-PEPTIDES, INC. (US) | 2025-03-25 | — | — | US | claimed |
| CN-119023646-A | Fingerprint reproduction device and reproduction method based on surface enhanced Raman substrate | 电子科技大学 | 2024-11-26 | — | — | CN | claimed |
| CN-118362674-B | Feature spectrum of Kemin capsule and content detection method of various quality markers | 山东省中医药研究院 | 2024-10-01 | — | — | CN | claimed |
| CN-118362674-A | Feature spectrum of Kemin capsule and content detection method of various quality markers | 山东省中医药研究院 | 2024-07-19 | — | — | CN | claimed |
| US-20240201155-A1 | Device for the Detection of Conditions Indicative of Illicit Drug Production | P ALERT LIMITED (NZ) | 2024-06-20 | — | — | US | claimed |
| CN-115980330-A | Fluorescent quantitative card for rapidly detecting 9 drugs and preparation method and application thereof | 江苏安科华捷生物科技有限公司 | 2023-04-18 | — | — | CN | claimed |
| US-20230062853-A1 | Methods and Compositions for Use of a Chemokine Receptor Antagonist Peptide to Treat Addiction, Substance Abuse Disorders or Symptoms Thereof | CREATIVE BIO-PEPTIDES, INC. | 2023-03-02 | — | — | US | claimed |
| CN-115252814-A | Cyclodextrin-metal organic framework composition and preparation method thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | claimed |
| CN-1230416-A | Combined application of pineal body, bezoar, date kernel, Radix Angelica Dahurica and Rhizoma corydalis in treating medicament dependence disease | TAO RAN (CN) | 1999-10-06 | — | — | CN | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| EP-0344675-B2 | Method for the production of selegiline hydrochloride | FARMAK A S (CS) | 1998-11-11 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-5023088-A | Drug delivery dispenser | ALZA CORPORATION (US) | 1991-06-11 | — | — | US | claimed |
| EP-0169057-B1 | METHOD AND APPARATUS FOR DETECTING A CONTRABAND SUBSTANCE | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1991-05-08 | — | — | EP | claimed |
| US-4718268-A | Method and apparatus for detecting a contraband substance | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1988-01-12 | — | — | US | claimed |
| EP-0169057-A2 | Method and apparatus for detecting a contraband substance | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1986-01-22 | — | — | EP | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |