Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.95 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.95 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL9114797 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL42099 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL1608168 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42098 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL9114800 | 1.00 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL13747483 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL15094315 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL20211416 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42615 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL727412 | 0.98 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4900 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122055143-A | Solid compositions containing bromhexine | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| US-12436136-B2 | Device for the detection of conditions indicative of illicit drug production | P ALERT LIMITED (NZ) | 2025-10-07 | — | — | US | claimed |
| EP-3793518-B1 | AN ORAL TABLET FOR TASTE MASKING OF ACTIVE INGREDIENTS COMPRISING NON-DIRECTLY COMPRESSIBLE SUGAR ALCOHOL PARTICLES | FERTIN PHARMA AS (DK) | 2025-03-26 | — | — | EP | claimed |
| US-12257283-B2 | Methods and compositions for use of a chemokine receptor antagonist peptide to treat addiction, substance abuse disorders or symptoms thereof | CREATIVE BIO-PEPTIDES, INC. (US) | 2025-03-25 | — | — | US | claimed |
| WO-2025033903-A1 | METHOD AND APPARATUS FOR IDENTIFYING DRUG ADDICT USING ARTIFICIAL INTELLIGENCE | 한양대학교 산학협력단 | 2025-02-13 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-12178804-B2 | Salts of cycloserine compounds and applications thereof | SYNEURX INTERNATIONAL (TAIWAN) CORP. (TW) | 2024-12-31 | — | — | US | claimed |
| CN-119023646-A | Fingerprint reproduction device and reproduction method based on surface enhanced Raman substrate | 电子科技大学 | 2024-11-26 | — | — | CN | claimed |
| EP-4088716-B1 | AN ORAL TABLET FOR INDUCED SALIVA GENERATION | FERTIN PHARMA AS (DK) | 2024-10-16 | — | — | EP | claimed |
| CN-118362674-B | Feature spectrum of Kemin capsule and content detection method of various quality markers | 山东省中医药研究院 | 2024-10-01 | — | — | CN | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-5102913-A | Treatment for cocaine use employing valproic acid | HALIKAS JAMES A (US) | 1992-04-07 | — | — | US | claimed |
| US-5028611-A | Treatment for cocaine use | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1991-07-02 | — | — | US | claimed |
| US-5023088-A | Drug delivery dispenser | ALZA CORPORATION (US) | 1991-06-11 | — | — | US | claimed |
| EP-0169057-B1 | METHOD AND APPARATUS FOR DETECTING A CONTRABAND SUBSTANCE | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1991-05-08 | — | — | EP | claimed |
| US-4718268-A | Method and apparatus for detecting a contraband substance | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1988-01-12 | — | — | US | claimed |
| EP-0238593-A1 | RECOVERY AND DOSING OF DNA IN AN ACELLULAR BIOLOGICAL LIQUID | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1987-09-30 | — | — | EP | claimed |
| WO-1987002064-A1 | RECOVERY AND DOSING OF DNA IN AN ACELLULAR BIOLOGICAL LIQUID | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M (FR) | 1987-04-09 | — | — | WO | claimed |
| EP-0169057-A2 | Method and apparatus for detecting a contraband substance | BRITISH AEROSPACE PUBLIC LIMITED COMPANY (GB) | 1986-01-22 | — | — | EP | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |