SCHEMBL4210123

SCHEMBL4210123

COc1cc(F)c(C(=O)O)cc1Cc1cccc(Cl)c1F

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 1/20 0.55
MRGPRX4 Q96LA9 5/20 0.43
CYP2C9 P11712 1/20 0.41
HIF1A Q16665 1/20 0.41
NOTUM Q6P988 1/20 0.41
PLA2G4A P47712 2/20 0.39
LMNA P02545 2/20 0.39
EGFR P00533 1/20 0.39
SCN9A Q15858 1/20 0.39
TP53 P04637 1/20 0.39
HTT P42858 1/20 0.39
CSF1R P07333 1/20 0.39
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1104891 0.91 METTL3 (0.56) METTL3MRGPRX4CYP2C9HIF1ANOTUM
Hydrochloric Acid SCHEMBL4211289 0.90 METTL3 (0.55) METTL3MRGPRX4CYP2C9HIF1ANOTUM
SCHEMBL4199027 0.90 METTL3 (0.48) METTL3CYP2C9LMNAEGFRSCN9A
SCHEMBL13927523 0.90 METTL3 (0.48) METTL3CYP2C9LMNAEGFRSCN9A
SCHEMBL14037269 0.89 METTL3 (0.55) METTL3MRGPRX4CYP2C9HIF1ANOTUM
SCHEMBL4205124 0.89 METTL3 (0.48) METTL3MRGPRX4CYP2C9LMNASCN9A
SCHEMBL13927525 0.86 METTL3 (0.46) METTL3MRGPRX4CYP2C9LMNAEGFR
SCHEMBL4214457 0.86 METTL3 (0.46) METTL3MRGPRX4LMNA
SCHEMBL13927547 0.85 METTL3 (0.47) METTL3PLA2G4ALMNAEGFRSCN9A
SCHEMBL4207612 0.85 METTL3 (0.50) METTL3MRGPRX4LMNAEGFRCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180265454-A1 Method for Producing 4-Oxoquinoline Compound JAPAN TOBACCO INC. (JP) 2018-09-20 US disclosed
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-10-22 US disclosed
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-10-22 US disclosed
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-10-22 US disclosed
EP-1992607-B9 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-07-01 EP disclosed
EP-1992607-B9 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-07-01 EP disclosed
EP-1992607-B1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2014-12-31 EP disclosed
EP-1992607-B1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2014-12-31 EP disclosed
US-20130310595-A1 Method for Producing 4-Oxoquinoline Compound JAPAN TOBACCO INC. (JP) 2013-11-21 US disclosed
US-20130310595-A1 Method for Producing 4-Oxoquinoline Compound JAPAN TOBACCO INC. (JP) 2013-11-21 US disclosed
CN-101437785-B Process for preparing 4-oxoquinoline compounds JAPAN TOBACCO INC 2013-05-29 CN disclosed
US-8383819-B2 Method for producing 4-oxoquinoline compound JAPAN TOBACCO INC. (JP) 2013-02-26 US disclosed
US-8383819-B2 Method for producing 4-oxoquinoline compound JAPAN TOBACCO INC. (JP) 2013-02-26 US disclosed
US-8383819-B2 Method for producing 4-oxoquinoline compound JAPAN TOBACCO INC. (JP) 2013-02-26 US disclosed
CN-101437785-A Process for preparing 4-oxoquinoline compounds JAPAN TOBACCO INC (JP) 2009-05-20 CN disclosed
US-20090036684-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND SHIONOGI & CO., LTD. (JP) 2009-02-05 US disclosed
US-20090036684-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND SHIONOGI & CO., LTD. (JP) 2009-02-05 US disclosed
US-20090036684-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND SHIONOGI & CO., LTD. (JP) 2009-02-05 US disclosed
EP-1992607-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND Japan Tobacco, Inc. (JP) 2008-11-19 EP disclosed
EP-1992607-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND Japan Tobacco, Inc. (JP) 2008-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND IMPDH1, IMPDH2, CDK20 METTL3 938/4885MRGPRX4 2814/4885CYP2C9 633/4885
US-20130310595-A1 Method for Producing 4-Oxoquinoline Compound IMPDH1, IMPDH2, CDK20 METTL3 938/4885MRGPRX4 2814/4885CYP2C9 633/4885
US-20180265454-A1 Method for Producing 4-Oxoquinoline Compound IMPDH1, IMPDH2, CDK20 METTL3 938/4885MRGPRX4 2814/4885CYP2C9 633/4885
US-20090036684-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND IMPDH1, IMPDH2, CDK20 METTL3 938/4885MRGPRX4 2814/4885CYP2C9 633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.