Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | PON1 | P27169 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425211 | 0.98 | — | — | |
| Iodide SCHEMBL14056822 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Bromide SCHEMBL5898632 | 0.96 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Fluoride Ion SCHEMBL4200159 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL16713822 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL17706400 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL6114821 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL6115333 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL1898065 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL899047 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071813-B2 | Methods of using ionic liquids having a fluoride anion as solvents | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2011-12-06 | — | — | US | disclosed |
| US-20090012297-A1 | Ionic liquids as solvents | ENERGY, U.S. DEPARTMENT OF | 2009-01-08 | — | — | US | disclosed |