Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 0.97 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.97 |
| ▸ | HTR1B | P28222 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | HTR7 | P34969 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.97 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.97 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.55 |
| ▸ | SCN4A | P35499 | 4/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL939869 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL4099920 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL408536 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Dexpramipexole SCHEMBL910147 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL2995942 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL4440257 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL28716749 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL743891 | 0.99 | DRD3 (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL2048695 | 0.99 | DRD3 (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL7106169 | 0.99 | ADRA2A (0.97) | ADRA2ADRD3DRD2DRD4HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6175 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12622895-B2 | Anti-neurodegenerative combinations and use for treatment of neurodegenerative diseases | ALTO NEUROSCIENCE, INC. (US) | 2026-05-12 | — | — | US | claimed |
| CN-223950344-U | Praziram hydrochloride tablet medicament lifting and transferring machine | 华裕(无锡)制药有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250329454-A1 | DIAGNOSTIC INDICES FOR NEURODEGENERATIVE CONDITIONS | CHASE THERAPEUTICS CORP (US) | 2025-10-23 | — | — | US | claimed |
| EP-4608388-A1 | COMBINATORIAL, AND ROTATIONAL COMBINATORIAL THERAPIES FOR OBESITY AND OTHER DISEASES | STARROCK PHARMA INC. (US) | 2025-09-03 | — | — | EP | claimed |
| EP-4558622-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | Trailhead Biosystems Inc. (US) | 2025-05-28 | — | — | EP | claimed |
| CN-120051560-A | Methods and compositions for generating human midbrain dopaminergic neurons from neural progenitor cells | 特雷尔赫德生物系统股份有限公司 | 2025-05-27 | — | — | CN | claimed |
| US-12310929-B2 | Use of rasagiline for the treatment of restless legs syndrome | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2025-05-27 | — | — | US | claimed |
| CN-119925280-A | Pramipexole dihydrochloride tablet and preparation method thereof | 山东则正医药技术有限公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119823062-A | Preparation method of pramipexole dihydrochloride related substance BI-II786BS | 中国医学科学院药物研究所 | 2025-04-15 | — | — | CN | claimed |
| WO-2004010997-A1 | SUSTAINED-RELEASE TABLET COMPOSITION OF PRAMIPEXOLE | PHARMACIA CORPORATION (US) | 2004-02-05 | — | — | WO | claimed |
| US-6645528-B1 | Rate of dissolution of drugs can be enhanced by making the drug into a porous matrix form | ACUSPHERE, INC. | 2003-11-11 | — | — | US | claimed |
| US-20030036548-A1 | Method for treating anhedonia using dopamine agonists | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-02-20 | — | — | US | claimed |
| WO-2002096422-A2 | COMBINATION OF A DOPAMINE D2-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-12-05 | — | — | WO | claimed |
| US-20020142050-A1 | Porous drug matrices and methods of manufacture thereof | ACUSPHERE INC. | 2002-10-03 | — | — | US | claimed |
| CN-1365274-A | Porous drug matrices and methods of making same | ACUSPHERE INC (US) | 2002-08-21 | — | — | CN | claimed |
| US-6410579-B2 | Use of pramipexole for the treatment of addictive disorders | PHARMACIA & UPJOHN COMPANY | 2002-06-25 | — | — | US | claimed |
| EP-1180020-A2 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | Acusphere, Inc. (US) | 2002-02-20 | — | — | EP | claimed |
| WO-2000072827-A9 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE INC (US) | 2002-01-31 | — | — | WO | claimed |
| WO-2000072827-A2 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE, INC. (US) | 2000-12-07 | — | — | WO | claimed |