Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 0.97 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.97 |
| ▸ | HTR1B | P28222 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | HTR7 | P34969 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.97 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.97 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.55 |
| ▸ | SCN4A | P35499 | 4/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL939869 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL4099920 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL42113 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL408536 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Dexpramipexole SCHEMBL910147 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL2995942 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL28716749 | 1.00 | ADRA2A (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL743891 | 0.99 | DRD3 (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL2048695 | 0.99 | DRD3 (1.00) | ADRA2ADRD3DRD2DRD4HRH2 | |
| Pramipexole SCHEMBL7106169 | 0.99 | ADRA2A (0.97) | ADRA2ADRD3DRD2DRD4HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003909-A2 | CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT | CHACHISVILIS MIRIANAS (US) | 2017-01-05 | — | — | WO | disclosed |
| CN-102124332-A | Separation and manipulation of chiral objects | DYNAMIC CONNECTIONS LLC | 2011-07-13 | — | — | CN | disclosed |
| EP-2134697-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | Dynamic Connections, Llc (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008130980-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | DYNAMIC CONNECTIONS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |