⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553464 | 0.68 | — | — | |
| SCHEMBL14034413 | 0.67 | — | — | |
| SCHEMBL6839510 | 0.63 | — | — | |
| SCHEMBL15577119 | 0.61 | POLB (0.32) | — | |
| SCHEMBL9243548 | 0.61 | ALDH1A1 (0.35) | — | |
| SCHEMBL19976220 | 0.60 | — | — | |
| SCHEMBL2521267 | 0.59 | — | — | |
| Hydrochloric Acid SCHEMBL15311921 | 0.57 | L3MBTL1 (0.31) | — | |
| SCHEMBL9165821 | 0.57 | — | — | |
| SCHEMBL9160807 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289481-B1 | METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-B]PYRAN-8-OL | PURDUE RESEARCH FOUNDATION (US) | 2025-09-17 | — | — | EP | disclosed |
| US-12365691-B2 | Method of synthesizing (3S,3AR,5R,7AS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol | PURDUE RESEARCH FOUNDATION (US) | 2025-07-22 | — | — | US | disclosed |
| US-20230399338-A1 | METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-b]PYRAN-8-OL | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-12-14 | — | — | US | disclosed |
| EP-4289481-A1 | METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-B]PYRAN-8-OL | Purdue Research Foundation (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-115768764-A | Fused ring compound with anti-tumor activity and application thereof | 上海翊石医药科技有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-114634512-A | Compound as Bruton's tyrosine kinase inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| US-9642847-B2 | Combinational compositions and methods for treatment of cancer | ARQULE, INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20160355515-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. | 2016-12-08 | — | — | US | disclosed |
| US-9447088-B2 | Compositions and methods for treatment of cancer | ARQULE, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160022667-A1 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE FORMULATIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE, INC. | 2016-01-28 | — | — | US | disclosed |
| WO-2009002806-A1 | PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| US-20070281955-A1 | RAF inhibitors and their uses | ARQULE, INC. | 2007-12-06 | — | — | US | disclosed |
| WO-2007123892-A2 | RAF INHIBITORS AND THEIR USES | ARQULE INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1846406-A1 | MALEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ArQule, Inc. (US) | 2007-10-24 | — | — | EP | disclosed |
| US-7241906-B2 | Bycyclic tetrahydrofuran derivatives and process for the preparation thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-07-10 | — | — | US | disclosed |
| WO-2007007939-A1 | BICYCLIC TETRAHYDROFURAN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007007938-A1 | TRICYCLIC TETRAHYDROFURAN LACTONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-01-18 | — | — | WO | disclosed |
| US-20070010576-A1 | Bycyclic tetrahydrofuran derivatives and process for the preparation thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY | 2007-01-11 | — | — | US | disclosed |
| US-20060223760-A1 | (+)-cis-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4(1H-indol-3-yl) pyrrolidine-2,5-dione; lung, colon, breast, pancreatic, prostate cancers, chronic myelogenous leukemia, melanoma, or ovarian cancer | ARQULE, INC. | 2006-10-05 | — | — | US | disclosed |
| WO-2006086484-A1 | MELEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2006-08-17 | — | — | WO | disclosed |