Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.37 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13876041 | 0.98 | HRH3 (0.42) | HRH3KDM4ETP53POLBCHEK1 | |
| SCHEMBL30639263 | 0.85 | KDM4E (0.47) | HRH3KDM4ETP53POLBCHEK1 | |
| Ammonia Solution, Strong SCHEMBL30639264 | 0.83 | KDM4E (0.46) | HRH3KDM4ETP53POLBCHEK1 | |
| Hydrochloric Acid SCHEMBL28679874 | 0.83 | KDM4E (0.46) | HRH3KDM4ETP53POLBCHEK1 | |
| SCHEMBL27894883 | 0.80 | ALDH1A1 (0.59) | HRH3KDM4ETP53POLBCHEK1 | |
| Iodide SCHEMBL2530875 | 0.79 | — | — | |
| SCHEMBL28288408 | 0.78 | TSHR (0.48) | HRH3KDM4ETP53POLB | |
| Hydrochloric Acid SCHEMBL28561999 | 0.75 | KDM4E (0.40) | HRH3KDM4ETP53POLBCHEK1 | |
| Thiocyanic Acid SCHEMBL27709180 | 0.75 | MAPT (0.32) | — | |
| Iodide SCHEMBL3820109 | 0.75 | MAPT (0.36) | POLBRAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877937-B2 | Process for preparing transition metal-carbene complexes | BASF SE (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20130178621-A1 | PROCESS FOR PREPARING TRANSITION METAL-CARBENE COMPLEXES | BASF SE (DE) | 2013-07-11 | — | — | US | disclosed |
| US-8410280-B2 | Process for preparing transition metal-carbene complexes | BASF SE (DE) | 2013-04-02 | — | — | US | disclosed |
| US-20090018330-A1 | PROCESS FOR PREPARING TRANSITION METAL-CARBENE COMPLEXES | BASF SE (DE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018330-A1 | PROCESS FOR PREPARING TRANSITION METAL-CARBENE COMPLEXES | AP1M1, C1S, GPS1 | HRH3 867/4885KDM4E 4586/4885TP53 651/4885 |
| US-20130178621-A1 | PROCESS FOR PREPARING TRANSITION METAL-CARBENE COMPLEXES | AP1M1, C1S, GPS1 | HRH3 867/4885KDM4E 4586/4885TP53 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.