Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.50 |
| ▸ | PPARA | Q07869 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019251 | 0.80 | PPARG (0.58) | PPARGPPARAKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL5766430 | 0.79 | CRBN (0.45) | POLBSMN1; SMN2HSD17B10ALDH1A1CRBN | |
| SCHEMBL13877020 | 0.79 | KDM4E (0.64) | KDM4EPOLBSMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL1931922 | 0.79 | ALDH1A1 (0.61) | PPARGPPARAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL29770828 | 0.79 | ALDH1A1 (0.61) | PPARGPPARAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL10294635 | 0.76 | POLB (0.58) | POLBHSD17B10NAPRTALDH1A1CRBN | |
| SCHEMBL27808295 | 0.75 | PPARG (0.65) | PPARGPPARALMNAALDH1A1GAA | |
| SCHEMBL4220016 | 0.74 | NPC1 (0.61) | KDM4ESMN1; SMN2LMNAHSD17B10ALDH1A1 | |
| SCHEMBL31478930 | 0.74 | PPARG (0.63) | PPARGPPARAKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL18518257 | 0.74 | POLB (0.55) | POLBHSD17B10NAPRTALDH1A1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1881968-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006120010-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | BDKRB1, IL1R1, IL1A | PPARG 1914/4885PPARA 2333/4885KDM4E 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.