Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triprolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 3/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | THPO | P40225 | 1/20 | 0.97 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triprolidine SCHEMBL9723510 | 1.00 | LMNA (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL42145 | 1.00 | LMNA (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL29730199 | 0.99 | LMNA (0.98) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL1140976 | 0.99 | LMNA (0.98) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL1140974 | 0.99 | LMNA (0.98) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL29631820 | 0.99 | KMT2A (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL4906 | 0.99 | KMT2A (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL3881294 | 0.99 | KMT2A (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL4905 | 0.99 | KMT2A (1.00) | LMNANPSR1GMNNBLMPMP22 | |
| Triprolidine SCHEMBL3273486 | 0.97 | KMT2A (0.97) | LMNANPSR1GMNNBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2437 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024239008-A1 | TRIACIN-C PRODUCT | STI PHARMA, LLC (US) | 2024-11-21 | — | — | WO | claimed |
| US-20240189227-A1 | EASY CHEW FORMULATIONS | HALEON US HOLDINGS LLC | 2024-06-13 | — | — | US | claimed |
| CN-118021984-A | Compound external preparation, preparation method and application thereof | 南方医科大学 | 2024-05-14 | — | — | CN | claimed |
| EP-4333895-A1 | EASY CHEW FORMULATIONS | Haleon US IP LLC (US) | 2024-03-13 | — | — | EP | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| CN-114073690-B | Extraction-preventing pharmaceutical composition containing amino acid and preparation thereof | 江苏长泰药业有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-114073689-B | Extraction-preventing pharmaceutical composition and preparation thereof | 江苏长泰药业有限公司 | 2024-01-12 | — | — | CN | claimed |
| EP-4126235-A2 | IDENTIFICATION AND USE OF COMPOUNDS IN THE TREATMENT OR PREVENTION OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 | Vanda Pharmaceuticals Inc. (US) | 2023-02-08 | — | — | EP | claimed |
| CN-115335122-A | Identification of compounds and their use in the treatment and prevention of severe acute respiratory syndrome coronavirus 2 | 万带兰制药公司 | 2022-11-11 | — | — | CN | claimed |
| WO-2022235989-A1 | EASY CHEW FORMULATIONS | GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC (US) | 2022-11-10 | — | — | WO | claimed |
| US-5141961-A | Mixing drug, polyethylene glycol, polyvinylpyrrolidone and solvent until dissolved, evaporating solvent | RICHRDSON-VICKS INC. (US) | 1992-08-25 | — | — | US | claimed |
| US-5098715-A | Core with flavor coating for drugs | BURROUGHS WELLCOME CO. (US) | 1992-03-24 | — | — | US | claimed |
| WO-1991009606-A1 | FREEZE-DRIED DOSAGE FORMS AND METHODS FOR PREPARING THE SAME | R.P. SCHERER CORPORATION (US) | 1991-07-11 | — | — | WO | claimed |
| EP-0435684-A1 | Freeze-dried dosage forms and methods for preparing the same | R.P. SCHERER CORPORATION (US) | 1991-07-03 | — | — | EP | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-0316345-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0316345-A4 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE. | LIPOSOME TECHNOLOGY INC (US) | 1989-05-16 | — | — | EP | claimed |
| EP-0298768-A2 | Flavoured film-coated tablet | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-01-11 | — | — | EP | claimed |
| WO-1988000824-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1988-02-11 | — | — | WO | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |