Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triprolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.97 |
| ▸ | GMNN | O75496 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triprolidine SCHEMBL29631820 | 1.00 | KMT2A (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL4906 | 1.00 | KMT2A (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL3881294 | 1.00 | KMT2A (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL9723510 | 0.99 | LMNA (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL42146 | 0.99 | LMNA (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL3273486 | 0.99 | KMT2A (0.97) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL42145 | 0.99 | LMNA (1.00) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL1140974 | 0.97 | LMNA (0.98) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL1140976 | 0.97 | LMNA (0.98) | KMT2ALMNASLC6A4ADRA1AHRH1 | |
| Triprolidine SCHEMBL14973526 | 0.97 | KMT2A (0.95) | KMT2ALMNASLC6A4ADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14979 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-4691492-A2 | LIQUID COMPOSITIONS | Kenvue Brands LLC (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4630401-A2 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | Rutgers, the State University of New Jersey (US) | 2025-10-15 | — | — | EP | claimed |
| EP-4247331-B1 | ORODISPERSIBLE POWDER COMPOSITION COMPRISING AN ANTIHISTAMINE COMPOUND | BIOPHARMA SYNERGIES S L (ES) | 2025-10-08 | — | — | EP | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| US-20250177398-A1 | CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2025-06-05 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| US-12296043-B2 | Liquisoft capsules | PATHEON SOFTGELS INC. (US) | 2025-05-13 | — | — | US | claimed |
| EP-0063649-B1 | NON-INVASIVE MEASURING DEVICE FOR LOCATING DRAINAGE AND CIRCULATION MALFUNCTIONS IN VEINS AND ARTERIES | Blazek, Vladimir, Dr.-Ing. (DE) | 1985-09-04 | — | — | EP | claimed |
| EP-0151987-A2 | Means for the treatment of diseases of the veins and the anal region | Ismail, Roshdy, Dr. (DE) | 1985-08-21 | — | — | EP | claimed |
| WO-1985000982-A1 | SYRINGE CONNECTABLE TO A VEIN CATHETER TO CONTROL ITS POSITION DURING ITS SETTING AND UTILIZATION | MAERZ PETER | 1985-03-14 | — | — | WO | claimed |
| EP-0117519-A1 | Catheter | Theermann, Johannes, Dipl.-Ing. (DE) | 1984-09-05 | — | — | EP | claimed |
| EP-0106304-A2 | Orthopaedic device | Best, Peter (DE) | 1984-04-25 | — | — | EP | claimed |
| EP-0082504-A1 | Catheter for the catheterisation of central veins | Sterimed Gesellschaft für medizinischen Bedarf mbH (DE) | 1983-06-29 | — | — | EP | claimed |
| WO-1983002064-A1 | CATHETER FOR CENTRAL VEINS | KRAMANN, BERNHARD | 1983-06-23 | — | — | WO | claimed |
| WO-1983001894-A1 | DEVICE FOR ELIMINATING OR EXPANDING STRICTURES IN VESSELS CONDUCTING BODY LIQUIDS | WEIKL, ANDREAS | 1983-06-09 | — | — | WO | claimed |
| EP-0063649-A1 | Non-invasive measuring device for locating drainage and circulation malfunctions in veins and arteries | Blazek, Vladimir, Dr.-Ing. (DE) | 1982-11-03 | — | — | EP | claimed |
| EP-0041696-A1 | Blood pressure measuring device | Rieckmann, Jutta, Geb. Federlein (DE) | 1981-12-16 | — | — | EP | claimed |