SCHEMBL421496

SCHEMBL421496

Nc1cccnc1SSc1ccccn1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APOBEC3G Q9HC16 2/20 0.63
▸ EHMT2 Q96KQ7 1/20 0.63
▸ EHMT1 Q9H9B1 1/20 0.63
▸ ALDH1A1 P00352 6/20 0.45
▸ HPGD P15428 4/20 0.45
▸ KDM4E B2RXH2 3/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ THRB P10828 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ MAPT P10636 3/20 0.40
▸ NOS3 P29474 1/20 0.39
▸ NOS1 P29475 1/20 0.39
▸ NOS2 P35228 1/20 0.39
▸ PI4KA P42356 1/20 0.39
▸ PI4K2B Q8TCG2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21174 0.79 EHMT2 (1.00) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL27972393 0.79 EHMT2 (1.00) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL29349787 0.79 EHMT2 (1.00) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL7205810 0.79 APOBEC3G (0.65) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL31005470 0.79 APOBEC3G (0.65) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL28571696 0.78 EHMT2 (0.63) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL28574713 0.78 EHMT2 (0.63) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
SCHEMBL31005457 0.78 EHMT2 (0.63) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
Hydrochloric Acid SCHEMBL10707236 0.77 EHMT2 (0.94) APOBEC3GEHMT2EHMT1ALDH1A1HPGD
Ammonia Solution, Strong SCHEMBL421495 0.77 EHMT2 (0.94) APOBEC3GEHMT2EHMT1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113039191-B Nucleotide analogues 奇异基因组学系统公司 2024-07-16 — — CN disclosed
US-11707483-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2023-07-25 — — US disclosed
CN-113039191-A Nucleotide analogs 奇异基因组学系统公司 2021-06-25 — — CN disclosed
US-20200147121-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2020-05-14 — — US disclosed
US-10420790-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2019-09-24 — — US disclosed
US-20170239360-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2017-08-24 — — US disclosed
US-9662403-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2017-05-30 — — US disclosed
US-20160250338-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2016-09-01 — — US disclosed
US-9339558-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2016-05-17 — — US disclosed
US-9211250-B2 Heterogeneous polymeric micelles for intracellular delivery UNIVERSITY OF WASHINGTON (US) 2015-12-15 — — US disclosed
EP-2331069-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY University Of Washington (US) 2011-06-15 — — EP disclosed
US-20110123636-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2011-05-26 — — US disclosed
EP-2296627-A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS The University of Washington (US) 2011-03-23 — — EP disclosed
EP-2296708-A2 POLYMERIC CARRIER University of Washington (US) 2011-03-23 — — EP disclosed
EP-2285853-A2 MICELLIC ASSEMBLIES University of Washington (US) 2011-02-23 — — EP disclosed
WO-2010053597-A2 MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS UNIVERSITY OF WASHINGTON/////////////////////-+ (US) 2010-05-14 — — WO disclosed
WO-2010021770-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY UNIVERSITY OF WASHINGTON (US) 2010-02-25 — — WO disclosed
WO-2009140429-A2 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2009-11-19 — — WO disclosed
WO-2009140432-A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF WASHINGTON (US) 2009-11-19 — — WO disclosed
WO-2009140421-A2 POLYMERIC CARRIER UNIVERSITY OF WASHINGTON (US) 2009-11-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11707483-B2 Micellic assemblies UACA, CLPTM1L, BPHL APOBEC3G 3677/4885EHMT2 4690/4885EHMT1 4514/4885
US-20160250338-A1 MICELLIC ASSEMBLIES CLPX, VCL, ANXA5 APOBEC3G 2954/4885EHMT2 4231/4885EHMT1 4203/4885
US-10420790-B2 Micellic assemblies UACA, CLPTM1L, BPHL APOBEC3G 3677/4885EHMT2 4690/4885EHMT1 4514/4885
US-20200147121-A1 MICELLIC ASSEMBLIES CLPX, VCL, ANXA5 APOBEC3G 2954/4885EHMT2 4231/4885EHMT1 4203/4885
US-20170239360-A1 MICELLIC ASSEMBLIES UACA, CLPTM1L, BPHL APOBEC3G 3677/4885EHMT2 4690/4885EHMT1 4514/4885
US-20110123636-A1 MICELLIC ASSEMBLIES CLPX, VCL, ANXA5 APOBEC3G 2954/4885EHMT2 4231/4885EHMT1 4203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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