Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309279 | 0.84 | APOBEC3G (0.45) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL27086278 | 0.81 | ALDH1A1 (0.54) | CFTRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL12491354 | 0.78 | MAPK1 (0.48) | CFTRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL27085913 | 0.78 | PDE4B (0.57) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL4213603 | 0.78 | CFTR (0.43) | CFTRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL4215711 | 0.77 | BRAF (0.67) | MEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL4222457 | 0.77 | TSHR (0.43) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL29193020 | 0.76 | ALDH1A1 (0.45) | CFTRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL27086050 | 0.76 | ALDH1A1 (0.42) | CFTRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL27088356 | 0.74 | KEAP1 (0.62) | MEN1KMT2AALDH1A1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383652-B2 | Biaromatic compounds that modulate PPAR-receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-02-26 | — | — | US | claimed |
| US-20090012129-A1 | NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-08 | — | — | US | claimed |
| US-8383652-B2 | Biaromatic compounds that modulate PPAR-receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-02-26 | — | — | US | disclosed |
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
| US-20090012129-A1 | NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-08 | — | — | US | disclosed |
| WO-2008067119-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008067119-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2007090141-A2 | PYRROLO [2, 3, B] PYRIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012129-A1 | NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS | PPARG, PPARD, PPARA | CFTR 1784/4885MEN1 4862/4885KMT2A 2532/4885 |
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | BRAF, RAF1, ARAF | CFTR 3632/4885MEN1 2187/4885KMT2A 1795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.