Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855369 | 0.87 | SCN9A (0.45) | TP53ELANENPC1RAB9AHPGD | |
| SCHEMBL1857119 | 0.85 | NPC1 (0.45) | TP53ELANENPC1RAB9AKMT2A | |
| SCHEMBL21874382 | 0.84 | HDAC1 (0.41) | NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL29510728 | 0.82 | MAP2K4 (0.45) | ELANENPC1RAB9AKMT2A | |
| SCHEMBL2478647 | 0.82 | MAP2K4 (0.45) | ELANENPC1RAB9AKMT2A | |
| SCHEMBL1863326 | 0.82 | ELANE (0.46) | ELANENPC1RAB9AHPGDKMT2A | |
| SCHEMBL4787612 | 0.81 | NPC1 (0.47) | TP53ELANENPC1RAB9AHPGD | |
| SCHEMBL3604733 | 0.80 | CHEK1 (0.50) | ELANENPC1RAB9AKMT2A | |
| SCHEMBL13318330 | 0.79 | DDB1 (0.41) | ELANENPC1RAB9AHPGDKMT2A | |
| SCHEMBL28337035 | 0.78 | ELANE (0.50) | ELANENPC1RAB9AHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2017265-A1 | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor | Abbott Laboratories (US) | 2009-01-21 | — | — | EP | disclosed |