Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 13/20 | 0.79 |
| ▸ | CA2 | P00918 | 6/20 | 0.79 |
| ▸ | CA9 | Q16790 | 5/20 | 0.79 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201987 | 1.00 | STS (0.79) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL4216787 | 1.00 | STS (0.79) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL4201982 | 1.00 | STS (0.79) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL1258427 | 0.95 | STS (0.75) | STSCA2CA9 | |
| SCHEMBL14070736 | 0.89 | STS (0.80) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL4212438 | 0.89 | STS (0.80) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL4212435 | 0.89 | STS (0.80) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL14549386 | 0.88 | STS (1.00) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL10071070 | 0.88 | STS (1.00) | STSCA2CA9CA1CYP1A2 | |
| SCHEMBL2451744 | 0.88 | STS (1.00) | STSCA2CA9CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221841-A1 | 2-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-YL SULFAMATE WITH AN ANTI-TUMOUR ACTION | STERIX LIMITED (GB) | 2009-09-03 | — | — | US | claimed |
| US-7427610-B2 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action | STERIX LIMITED (GB) | 2008-09-23 | — | — | US | claimed |
| US-8492570-B2 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumor action | STERIX LIMITED (GB) | 2013-07-23 | — | — | US | disclosed |
| US-20090221841-A1 | 2-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-YL SULFAMATE WITH AN ANTI-TUMOUR ACTION | STERIX LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-7427610-B2 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action | STERIX LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-20060160782-A1 | 2-Substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action | STERIX LIMITED (GB) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160782-A1 | 2-Substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action | SULT1E1, SULT1A1, SULT2A1 | STS 5/4885CA2 812/4885CA9 816/4885 |
| US-20090221841-A1 | 2-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-YL SULFAMATE WITH AN ANTI-TUMOUR ACTION | SULT1E1, SULT1A1, SULT2A1 | STS 5/4885CA2 805/4885CA9 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.