Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13394483 | 0.79 | PKM (0.50) | PKMLMNAMAOASLC6A2USP2 | |
| SCHEMBL22463649 | 0.74 | OPRL1 (0.40) | OPRL1CYP17A1CYP11B1CYP11B2ADORA3 | |
| SCHEMBL12480396 | 0.74 | OPRL1 (0.40) | OPRL1CYP17A1CYP11B1CYP11B2ADORA3 | |
| SCHEMBL13547538 | 0.73 | DDB1 (0.39) | PKMLMNAUSP2ALDH1A1HPGD | |
| SCHEMBL28680491 | 0.71 | OPRL1 (0.44) | OPRL1CYP17A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL28680489 | 0.71 | OPRL1 (0.44) | OPRL1CYP17A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL29368373 | 0.71 | OPRL1 (0.44) | OPRL1CYP17A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL5021231 | 0.71 | CHRNB2 (0.46) | CYP11B1CYP11B2 | |
| SCHEMBL10243298 | 0.71 | CHRNB2 (0.46) | CYP11B1CYP11B2 | |
| SCHEMBL9243943 | 0.68 | MAOB (0.44) | PKMLMNAMAOASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029560-A2 | 1,3-OXAZOLIDIN-2-ONE DERIVATIVES USEEFUL AS CETP INHIBITORS | Merck & Co., Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007079186-A2 | 1, 3-OXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS CETP INHIBITORS | MERCK & CO., INC. (US) | 2007-07-12 | — | — | WO | disclosed |