Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | PGR | P06401 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | AR | P10275 | 2/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.69 |
| ▸ | RELA | Q04206 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | APEX1 | P27695 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355683 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL28868471 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL5262836 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL4217810 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL12396656 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL3158085 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL3158091 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL5261130 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL22414814 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 | |
| SCHEMBL13928663 | 1.00 | KDM4E (0.71) | KDM4EHIF1ACYP3A4NR3C1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3947409-A | 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof | MERCK & CO., INC. (US) | 1976-03-30 | — | — | US | claimed |
| US-8785425-B2 | 11β-hydroxyandrosta-4-ene-3-ones | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. | 2014-07-22 | — | — | US | disclosed |
| EP-2004667-B1 | NOVEL 11 BETA - HYDROXYANDROSTA-4-ENE-3-ONES | SUN PHARMA ADVANCED RES CO LTD (IN) | 2013-09-04 | — | — | EP | disclosed |
| US-20090054388-A1 | NOVEL 11 BETA-HYDROXYANDROSTA-4-ENE-3-ONES | SUN PHARMA ADVANCE RESEARCH COMPANY (IN) | 2009-02-26 | — | — | US | disclosed |
| US-3947409-A | 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof | MERCK & CO., INC. (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054388-A1 | NOVEL 11 BETA-HYDROXYANDROSTA-4-ENE-3-ONES | HSD11B1, HSD3B1, HSD3B2 | KDM4E 2871/4885HIF1A 1534/4885CYP3A4 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.