Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419650 | 0.90 | HSD11B1 (0.45) | HSD11B1HSD11B2PTPN1GPBAR1RORC | |
| SCHEMBL422274 | 0.89 | PTPN1 (0.57) | HSD11B1HSD11B2PTPN1GPBAR1CES2 | |
| SCHEMBL1721265 | 0.87 | PTPN1 (0.58) | PTPN1GPBAR1CES2TOP2ACES1 | |
| SCHEMBL420482 | 0.87 | CA9 (0.49) | HSD11B1HSD11B2 | |
| SCHEMBL418815 | 0.87 | HSD11B1 (0.43) | HSD11B1HSD11B2PTPN1GPBAR1 | |
| SCHEMBL418949 | 0.85 | HSD11B1 (0.59) | HSD11B1HSD11B2PTPN1CES2CES1 | |
| SCHEMBL419704 | 0.84 | PTPN1 (0.52) | PTPN1GPBAR1CES2TOP2ACES1 | |
| SCHEMBL423196 | 0.82 | PTPN1 (0.55) | PTPN1GPBAR1CES2TOP2ACES1 | |
| SCHEMBL1721671 | 0.80 | GPBAR1 (0.46) | PTPN1GPBAR1CES2CES1 | |
| SCHEMBL14350531 | 0.80 | PTPN1 (0.65) | PTPN1GPBAR1CES2TOP2ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476315-B2 | N-hydroxy C29-amide derivatives of oleandrane | ONEPHARM RESEARCH & DEVELOPMENT GMBH (AT) | 2013-07-02 | — | — | US | disclosed |
| US-20120022154-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | ONEPHARM RESEARCH & DEVELOPMENT GMBH (AT) | 2012-01-26 | — | — | US | disclosed |
| EP-2228380-A1 | Novel triterpene derivatives | onepharm Research & Development GmbH (AT) | 2010-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022154-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | HSD11B1, CYP11B1, HSD11B2 | HSD11B1 1/4885HSD11B2 3/4885PTPN1 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.