Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.52 |
| ▸ | RORC | P51449 | 3/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GLI1 | P08151 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422821 | 0.90 | RORC (0.42) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL423196 | 0.89 | PTPN1 (0.55) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL419086 | 0.87 | HSD11B1 (0.47) | — | |
| SCHEMBL422987 | 0.87 | HSD11B1 (0.41) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL422227 | 0.84 | CES2 (0.44) | PTPN1RORCCES2CES1LMNA | |
| SCHEMBL421828 | 0.84 | HSD11B1 (0.55) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL1721265 | 0.83 | PTPN1 (0.58) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL422274 | 0.83 | PTPN1 (0.57) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL421444 | 0.79 | PTPN1 (0.44) | PTPN1RORCGPBAR1CES2TOP2A | |
| SCHEMBL851609 | 0.79 | PTPN1 (0.65) | PTPN1RORCGPBAR1CES2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476315-B2 | N-hydroxy C29-amide derivatives of oleandrane | ONEPHARM RESEARCH & DEVELOPMENT GMBH (AT) | 2013-07-02 | — | — | US | disclosed |
| US-20120022154-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | ONEPHARM RESEARCH & DEVELOPMENT GMBH (AT) | 2012-01-26 | — | — | US | disclosed |
| EP-2228380-A1 | Novel triterpene derivatives | onepharm Research & Development GmbH (AT) | 2010-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022154-A1 | N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE | HSD11B1, CYP11B1, HSD11B2 | PTPN1 4379/4885RORC 512/4885GPBAR1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.