Columbamine

Columbamine

SCHEMBL422073

COc1cc2c(cc1O)-c1cc3ccc(OC)c(OC)c3c[n+]1CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 1.00
KDM1A O60341 4/20 1.00
MAPT P10636 5/20 0.91
RAD52 P43351 5/20 0.91
LMNA P02545 4/20 0.91
KDM4E B2RXH2 3/20 0.91
SMN1; SMN2 Q16637 3/20 0.91
POLB P06746 1/20 0.91
GAA P10253 1/20 0.91
TRPC5 Q9UL62 1/20 0.91
CYP1B1 Q16678 3/20 0.89
RAC1 P63000 2/20 0.89
ACHE P22303 7/20 0.87
MAOB P27338 1/20 0.87
EP300 Q09472 6/20 0.83
CYP2D6 P10635 3/20 0.83
MAPK1 P28482 2/20 0.83
HIF1A Q16665 2/20 0.83
APP P05067 1/20 0.80
ALDH1A1 P00352 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Columbamine SCHEMBL29395690 1.00 CYP3A4 (1.00) CYP3A4KDM1AMAPTRAD52LMNA
Columbamine SCHEMBL3324164 0.99 CYP3A4 (0.98) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL564128 0.95 CYP3A4 (1.00) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL29368316 0.95 CYP3A4 (1.00) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL29381269 0.95 CYP3A4 (1.00) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL31238510 0.94 CYP3A4 (0.98) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL21809027 0.94 CYP3A4 (0.98) CYP3A4KDM1AMAPTRAD52LMNA
Jatrorrhizine SCHEMBL1427435 0.94 CYP3A4 (0.98) CYP3A4KDM1AMAPTRAD52LMNA
SCHEMBL2742479 0.94 RAC1 (1.00) CYP3A4KDM1AMAPTRAD52LMNA
Columbamine SCHEMBL8858971 0.94 CYP3A4 (0.88) CYP3A4KDM1AMAPTRAD52LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 486 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4687856-A2 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS Therapeutics, LLC (US) 2026-02-11 EP claimed
WO-2024229159-A2 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS THERAPEUTICS, LLC (US) 2024-11-07 WO claimed
US-20240366525-A1 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS THERAPEUTICS, LLC 2024-11-07 US claimed
WO-2024197225-A1 REDOX ACTIVE ANTIFOULING COATINGS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-09-26 WO claimed
US-20230172916-A1 COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME ELEONOR (BE) 2023-06-08 US claimed
EP-4135666-A1 COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME Eleonor (BE) 2023-02-22 EP claimed
EP-3954371-A1 ANTI-ACETYLCHOLINESTERASE ACTIVE COMPOSITION IN CAULIS MAHONIAE AND SCREENING METHOD THEREFOR AND APPLICATION THEREOF Shenzhen Institute for Drug Control (Shenzhen Testing Center of Medical Devices) (CN) 2022-02-16 EP claimed
WO-2021209623-A1 COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME ELEONOR SPRL (BE) 2021-10-21 WO claimed
US-20200230118-A1 USE OF BERBERINE OR ACTIVE METABOLITE THEREOF IN PREPARATION OF DRUG FOR PREVENTING AND/OR TREATING PHENYLKETONURIA INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2020-07-23 US claimed
EP-3672575-A1 COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND ITS PRODUCTION PROCESS Eleonor SPRL (BE) 2020-07-01 EP claimed
WO-2006091676-A2 MODULATING PLANT ALKALOIDS CERES INC. (US) 2006-08-31 WO claimed
CN-1725991-A Delivery of peroxide producing enzymes to the vagina KIMBERLY CLARK CO (US) 2006-01-25 CN claimed
EP-1578317-A2 DELIVERY OF PEROXIDE-GENERATING ENZYMES TO THE VAGINAL TRACT Kimberly-Clark Worldwide, Inc. (US) 2005-09-28 EP claimed
CN-1190425-C Six kinds of isoquinoline alkaloid SHANGHAI MEDICINE INST CHINESE (CN) 2005-02-23 CN claimed
WO-2004060272-A2 DELIVERY OF PEROXIDE-GENERATING ENZYMES TO THE VAGINAL TRACT KIMBERLY-CLARK WORLDWIDE, INC. (US) 2004-07-22 WO claimed
US-20040126369-A1 Delivery of peroxide-generating enzymes to the vaginal tract KIMBERLY-CLARK WORLDWIDE, INC. 2004-07-01 US claimed
US-20040091556-A1 Nasal irrigation solutions and methods of using same TIGUNAIT RAJMANI (US) 2004-05-13 US claimed
WO-2004011017-A1 NASAL IRRIGATION SOLUTIONS AND METHODS OF USING SAME HIMALAYAN INTERNATIONAL INSTITUTE OF YOGA SCIENCE AND PHILOSOPHY (US) 2004-02-05 WO claimed
CN-1314347-A Six kinds of isoquinoline alkaloid SHANGHAI MEDICINE INST CHINESE (CN) 2001-09-26 CN claimed
WO-2001007034-A1 MULTIDRUG RESISTANCE PUMP INHIBITORS AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2001-02-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230172916-A1 COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME MANBA, CROCC, MAN2A1 CYP3A4 1385/4885KDM1A 4875/4885MAPT 1504/4885
US-20200230118-A1 USE OF BERBERINE OR ACTIVE METABOLITE THEREOF IN PREPARATION OF DRUG FOR PREVENTING AND/OR TREATING PHENYLKETONURIA PAH, BCKDK, BHMT CYP3A4 215/4885KDM1A 1460/4885MAPT 1424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.