Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4221760 | 1.00 | JAK2 (0.51) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL4217096 | 0.95 | ROCK2 (0.51) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL4217086 | 0.95 | ROCK2 (0.51) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL4227610 | 0.92 | SIGMAR1 (0.49) | JAK1ROCK2ROCK1CCR2SIGMAR1 | |
| SCHEMBL4227618 | 0.92 | SIGMAR1 (0.49) | JAK1ROCK2ROCK1CCR2SIGMAR1 | |
| SCHEMBL4229313 | 0.91 | HDAC8 (0.55) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL4229330 | 0.91 | HDAC8 (0.55) | JAK2JAK1TYK2JAK3ROCK2 | |
| Hydrochloric Acid SCHEMBL4228509 | 0.91 | HDAC8 (0.55) | JAK2JAK1TYK2JAK3ROCK2 | |
| Hydrochloric Acid SCHEMBL4228518 | 0.91 | HDAC8 (0.55) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL4215265 | 0.90 | BCHE (0.49) | JAK2JAK1TYK2JAK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557127-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20090054464-A1 | HDAC INHIBITOR | ASTELLAS PHARMA INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| US-7465731-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2008-12-16 | — | — | US | disclosed |
| US-20060052599-A1 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052599-A1 | HDAC inhibitor | HDAC1, HDAC2, HDAC11 | JAK2 1495/4885JAK1 3077/4885TYK2 1259/4885 |
| US-20090054464-A1 | HDAC INHIBITOR | HDAC1, HDAC2, HDAC8 | JAK2 1640/4885JAK1 3296/4885TYK2 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.