Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623848 | 0.79 | BCAT2 (0.55) | MAPK8LMNAKMT2A | |
| SCHEMBL24318549 | 0.78 | CYP2A6 (0.66) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL6669302 | 0.77 | BCAT2 (0.68) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL28019336 | 0.75 | MKNK1 (0.58) | CYP2A6CYP3A4MKNK1MKNK2F7 | |
| SCHEMBL30514275 | 0.75 | BCAT2 (0.67) | CYP2A6MKNK1MKNK2F7F3 | |
| SCHEMBL167082 | 0.75 | BCAT2 (0.67) | CYP2A6MKNK1MKNK2F7F3 | |
| SCHEMBL27880990 | 0.75 | MKNK1 (0.58) | CYP2A6CYP3A4MKNK1MKNK2F7 | |
| SCHEMBL31227976 | 0.75 | BCAT2 (0.67) | CYP2A6MKNK1MKNK2F7F3 | |
| Hydrochloric Acid SCHEMBL30165666 | 0.73 | BCAT2 (0.65) | CYP2A6MKNK1MKNK2F7F3 | |
| Hydrochloric Acid SCHEMBL27890957 | 0.73 | BCAT2 (0.65) | CYP2A6MKNK1MKNK2F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-20060281666-A1 | Substitute thiophenes and uses therof | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | TPMT, ABCG2, TYMP | CYP2A6 143/4885CYP3A4 57/4885CYP2C19 62/4885 |
| US-20060281666-A1 | Substitute thiophenes and uses therof | TYMP, TPMT, MGMT | CYP2A6 747/4885CYP3A4 808/4885CYP2C19 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.