SCHEMBL6669302

SCHEMBL6669302

NC(=O)c1sccc1-c1cccnc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.68
CYP2A6 P11509 5/20 0.57
CYP3A4 P08684 4/20 0.54
CYP2C19 P33261 2/20 0.54
CYP1A2 P05177 2/20 0.54
LMNA P02545 1/20 0.54
MKNK1 Q9BUB5 7/20 0.53
MKNK2 Q9HBH9 7/20 0.53
LIMK1 P53667 1/20 0.49
F7 P08709 1/20 0.47
F3 P13726 1/20 0.47
SARM1 Q6SZW1 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.47
SIRT6 Q8N6T7 1/20 0.47
SIRT1 Q96EB6 1/20 0.47
SIRT3 Q9NTG7 1/20 0.47
SIRT5 Q9NXA8 1/20 0.47
SIRT4 Q9Y6E7 1/20 0.47
CYP2E1 P05181 2/20 0.46
CYP2C9 P11712 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27691411 0.85 CYP2A6 (0.58) BCAT2CYP2A6CYP3A4CYP2C19CYP1A2
SCHEMBL6667283 0.81 BCAT2 (0.69) BCAT2IKBKBALDH1A1CHEK2
SCHEMBL4445671 0.81 BCAT2 (1.00) BCAT2CYP3A4CYP1A2LMNACYP2C9
SCHEMBL27691396 0.80 GABRA1 (0.60) CYP2A6CYP3A4CYP2C19CYP1A2CYP2E1
Hydrochloric Acid SCHEMBL31228833 0.80 BCAT2 (0.96) BCAT2CYP3A4CYP1A2LMNACYP2C9
SCHEMBL4221979 0.77 CYP2A6 (0.57) CYP2A6CYP3A4CYP2C19CYP1A2LMNA
SCHEMBL31661826 0.77 BCAT2 (0.54) BCAT2CYP2A6CYP3A4CYP2C19CYP1A2
SCHEMBL31661861 0.77 BCAT2 (0.54) BCAT2CYP3A4CYP2C19CYP1A2MKNK2
SCHEMBL31661900 0.76 BCAT2 (0.57) BCAT2CYP3A4CYP2C19CYP1A2LMNA
SCHEMBL27711486 0.76 BCAT2 (0.49) BCAT2CYP2A6CYP1A2LIMK1F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112004807-B Compounds and pharmaceutical compositions comprising the same 自体吞噬科学有限公司 2023-07-18 CN claimed
CN-112004807-A Novel compounds and pharmaceutical compositions comprising said compounds 自体吞噬科学有限公司 2020-11-27 CN claimed
CN-101098870-B Novel fused imidazole derivative BANYU PHARMA CO LTD 2010-11-03 CN claimed
CN-101098870-A Novel fused imidazole derivative BANYU PHARMA CO LTD (JP) 2008-01-02 CN claimed
CN-1400973-A Novel biarylcarboxamides ASTRAZENECA AB (SE) 2003-03-05 CN claimed
WO-2025151311-A1 NICOTINAMIDE DERIVATIVES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-07-17 WO disclosed
CN-112004807-B Compounds and pharmaceutical compositions comprising the same 自体吞噬科学有限公司 2023-07-18 CN disclosed
CN-112004807-A Novel compounds and pharmaceutical compositions comprising said compounds 自体吞噬科学有限公司 2020-11-27 CN disclosed
CN-101098870-B Novel fused imidazole derivative BANYU PHARMA CO LTD 2010-11-03 CN disclosed
CN-101098870-A Novel fused imidazole derivative BANYU PHARMA CO LTD (JP) 2008-01-02 CN disclosed
EP-1453828-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME AstraZeneca AB (SE) 2004-09-08 EP disclosed
WO-2003032897-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME ASTRAZENECA AB (SE) 2003-04-24 WO disclosed