Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437916 | 0.86 | KDM1A (0.39) | KDM1APGRDRD2DRD3PNMT | |
| SCHEMBL733031 | 0.79 | KDM1A (0.36) | KDM1APGR | |
| SCHEMBL731436 | 0.76 | KDM1A (0.35) | KDM1APGRDRD2DRD3 | |
| SCHEMBL733341 | 0.66 | KDM1A (0.35) | KDM1APGRDRD2DRD3 | |
| SCHEMBL4045639 | 0.64 | KDM1A (0.34) | KDM1APGRDRD2DRD3 | |
| SCHEMBL732031 | 0.63 | KDM1A (0.46) | KDM1ACYP19A1CYP11B1CYP11B2PGR | |
| SCHEMBL17987977 | 0.58 | KDM1A (1.00) | KDM1ADRD2DRD3PNMT | |
| SCHEMBL8746261 | 0.57 | KDM1A (0.47) | KDM1ACYP19A1CYP11B1CYP11B2PGR | |
| SCHEMBL4226656 | 0.57 | CYP19A1 (0.61) | KDM1ACYP19A1CYP11B1CYP11B2DRD2 | |
| SCHEMBL4219622 | 0.57 | CYP19A1 (0.61) | KDM1ACYP19A1CYP11B1CYP11B2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010540-B1 | SPIRO-IMIDAZO COMPOUNDS | NOVARTIS AG (CH) | 2012-12-05 | — | — | EP | disclosed |
| EP-2010540-A1 | SPIRO-IMIDAZO COMPOUNDS | Speedel Experimenta AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007116098-A1 | SPIRO-IMIDAZO COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2007-10-18 | — | — | WO | disclosed |