Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437916 | 0.83 | KDM1A (0.39) | KDM1AEP300CREBBPPGRCXCR5 | |
| SCHEMBL731360 | 0.80 | DRD2 (0.33) | KDM1AEP300CREBBPPGRSYK | |
| SCHEMBL4222657 | 0.79 | KDM1A (0.40) | KDM1APGR | |
| SCHEMBL2917019 | 0.64 | PTGES (0.35) | PTGESALOX5PPARG | |
| SCHEMBL4045639 | 0.62 | KDM1A (0.34) | KDM1AEP300CREBBPPGRCXCR5 | |
| SCHEMBL731083 | 0.61 | DRD2 (0.33) | KDM1AEP300CREBBPPGRSYK | |
| SCHEMBL733341 | 0.61 | KDM1A (0.35) | KDM1APGRSYK | |
| SCHEMBL17988227 | 0.60 | KDM1A (0.66) | KDM1APGRCXCR5 | |
| SCHEMBL4495832 | 0.59 | KDM1A (0.42) | KDM1AEP300CREBBPCXCR5 | |
| SCHEMBL4495829 | 0.59 | KDM1A (0.42) | KDM1AEP300CREBBPCXCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138179-B2 | Spiro-imidazo compounds | NOVARTIS AG (CH) | 2012-03-20 | — | — | US | disclosed |