Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746287 | 0.83 | KDM1A (0.47) | KDM1ASYKPGRCYP11B2CYP11B1 | |
| SCHEMBL9263133 | 0.81 | CYP3A4 (0.41) | SYKPGRCYP11B2CYP11B1CYP3A4 | |
| SCHEMBL8746293 | 0.81 | KDM1A (0.44) | KDM1APGRCYP11B2CYP11B1CYP3A4 | |
| SCHEMBL8746223 | 0.81 | KDM1A (0.47) | KDM1ASYKPGRCYP11B2CYP11B1 | |
| SCHEMBL732031 | 0.72 | KDM1A (0.46) | KDM1ASYKPGRCYP11B2CYP11B1 | |
| SCHEMBL731222 | 0.66 | PGR (0.43) | KDM1ASYKPGRCYP11B2CYP11B1 | |
| SCHEMBL4808214 | 0.66 | KDM1A (0.49) | KDM1APGRDRD2DRD3PNMT | |
| SCHEMBL28875599 | 0.66 | KDM1A (0.49) | KDM1APGRDRD2DRD3PNMT | |
| SCHEMBL13599735 | 0.65 | PGR (0.49) | KDM1APGRCYP11B2CYP11B1CYP3A4 | |
| SCHEMBL17987977 | 0.64 | KDM1A (1.00) | KDM1ADRD2DRD3PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477141-B1 | Heteroarylmethylbenzols aromatase inhibitors | CIBA GEIGY AG (CH) | 1997-02-26 | — | — | EP | disclosed |
| US-5378721-A | AROMATASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1995-01-03 | — | — | US | disclosed |
| US-5246952-A | Antitumor agents | CIBA-GEIGY CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0477141-A1 | Heteroarylmethylbenzols aromatase inhibitors | CIBA-GEIGY AG (CH) | 1992-03-25 | — | — | EP | disclosed |