Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | HSF1 | Q00613 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044416 | 0.73 | PTGS2 (0.43) | NR1H3ALDH1A1MPOHSF1 | |
| SCHEMBL6134029 | 0.68 | HSD17B10 (0.42) | NR1H3ALDH1A1 | |
| SCHEMBL10044414 | 0.68 | HSD17B10 (0.39) | NR1H3ALDH1A1POLBKMT2AMPO | |
| SCHEMBL12519609 | 0.67 | NR1H3 (0.42) | NR1H3ALDH1A1POLBKMT2AMPO | |
| SCHEMBL2936034 | 0.66 | ALDH1A1 (0.41) | TOP2ANR1H3ALDH1A1POLBKMT2A | |
| SCHEMBL7803958 | 0.65 | HSD17B10 (0.45) | NR1H3ALDH1A1KMT2A | |
| SCHEMBL10284719 | 0.64 | NR1H3 (0.40) | NR1H3KMT2AMPO | |
| SCHEMBL8859418 | 0.63 | HSD17B10 (0.44) | ALDH1A1 | |
| SCHEMBL18770684 | 0.63 | KAT2B (0.42) | ALDH1A1 | |
| SCHEMBL13236896 | 0.63 | TOP2A (0.38) | TOP2ANR1H3ALDH1A1MPOHSF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494996-B2 | Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones and their use as fungicides and insecticides | DOW AGROSCIENCES LLC (US) | 2009-02-24 | — | — | US | disclosed |
| EP-1337150-A4 | SUBSTITUTED 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES, 1,2,4-TRIAZIN-6-ONES, AND THEIR USE AS FUNGICIDES AND INSECTICIDES | DOW AGROSCIENCES LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20040242580-A1 | Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones and their use as fungicides and insecticides | KELLY MARTHA JEAN (US) | 2004-12-02 | — | — | US | disclosed |
| EP-1337150-A2 | SUBSTITUTED 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES, 1,2,4-TRIAZIN-6-ONES, AND THEIR USE AS FUNGICIDES AND INSECTICIDES | Dow AgroSciences LLC (US) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002067675-A2 | SUBSTITUTED 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES, 1,2,4-TRIAZIN-6-ONES, AND THEIR USE AS FUNGICIDES AND INSECTICIDES | DOW AGROSCIENCES LLC (US) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242580-A1 | Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones and their use as fungicides and insecticides | DDT, CYP4B1, CYP4X1 | TOP2A 551/4885NR1H3 2586/4885ALDH1A1 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.