Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BCL3 | P20749 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4220624 | 0.97 | CD274 (0.38) | CD274JAK2PDCD1ALDH1A1MAPK14 | |
| SCHEMBL3234115 | 0.89 | CD274 (0.40) | CD274JAK2KMT2AALDH1A1POLB | |
| SCHEMBL3225520 | 0.88 | ALDH1A1 (0.47) | CD274PDCD1MEN1NPC1RAB9A | |
| SCHEMBL3219036 | 0.88 | CD274 (0.41) | CD274JAK2KMT2AALDH1A1POLB | |
| SCHEMBL3224363 | 0.87 | TACR2 (0.44) | CD274JAK2ALDH1A1EPHX2BCL3 | |
| SCHEMBL3227868 | 0.87 | SIGMAR1 (0.39) | CD274JAK2MEN1KMT2AALDH1A1 | |
| SCHEMBL4224516 | 0.87 | HDAC1 (0.39) | POLBBCL3 | |
| SCHEMBL3228228 | 0.86 | SIGMAR1 (0.40) | CD274JAK2MEN1KMT2AALDH1A1 | |
| SCHEMBL3230156 | 0.86 | JAK2 (0.38) | CD274JAK2PDCD1ALDH1A1EPHX2 | |
| SCHEMBL3230756 | 0.86 | EPHX2 (0.46) | CD274JAK2EPHX2POLBCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |