Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.69 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28215958 | 0.83 | SLC22A6 (0.48) | SLC22A6PBRM1GSK3BLMNANR4A2 | |
| Indole Acetate SCHEMBL15553 | 0.82 | SLC22A6 (1.00) | SLC22A6PBRM1GSK3BLMNANR4A2 | |
| SCHEMBL27790479 | 0.81 | MAPK1 (0.52) | SLC22A6PBRM1GSK3BNR4A2CREBBP | |
| Indole Acetate SCHEMBL28825383 | 0.81 | SLC22A6 (0.97) | SLC22A6PBRM1GSK3BLMNANR4A2 | |
| Indole Acetate SCHEMBL14576593 | 0.81 | SLC22A6 (0.97) | SLC22A6PBRM1GSK3BLMNANR4A2 | |
| Indole Acetate SCHEMBL14576776 | 0.81 | SLC22A6 (0.97) | SLC22A6PBRM1GSK3BLMNANR4A2 | |
| SCHEMBL8676653 | 0.80 | PTGS2 (0.61) | SLC22A6PDE5ALMNA | |
| SCHEMBL27494000 | 0.79 | PDGFRB (0.51) | GSK3BNR4A2SIRT2SIRT1MAPT | |
| SCHEMBL8945241 | 0.77 | KDM4E (0.51) | SLC22A6PBRM1LMNAMAPT | |
| Indole Acetate SCHEMBL28648551 | 0.75 | SLC22A6 (0.82) | SLC22A6PBRM1LMNANR4A2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |