Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231672 | 0.85 | IDO1 (0.42) | NPC1TLR7TLR9TLR8ESR1 | |
| SCHEMBL4229742 | 0.84 | TLR7 (0.41) | TLR7TLR9TLR8ESR1ADORA2A | |
| SCHEMBL4046724 | 0.83 | TLR7 (0.48) | TLR7TLR9TLR8PIK3CAADORA1 | |
| SCHEMBL4224372 | 0.82 | TLR9 (0.39) | TLR7TLR9TLR8ESR1PIK3CA | |
| SCHEMBL4219371 | 0.82 | ESR1 (0.57) | NPC1TLR7TLR9TLR8ESR1 | |
| SCHEMBL4227399 | 0.81 | TLR7 (0.41) | TLR7TLR9TLR8ESR1GFER | |
| SCHEMBL4214893 | 0.81 | TLR7 (0.54) | TLR7TLR9TLR8PIK3CAADORA1 | |
| SCHEMBL4224648 | 0.81 | TLR7 (0.48) | TLR7TLR9TLR8PIK3CA | |
| SCHEMBL4259100 | 0.81 | TLR7 (0.41) | TLR7TLR9TLR8ESR1RPS6KA3 | |
| SCHEMBL4216196 | 0.80 | TLR7 (0.59) | TLR7TLR9TLR8ESR1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2016-10-20 | — | — | US | claimed |
| US-20180125849-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2018-05-10 | — | — | US | disclosed |
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2016-10-20 | — | — | US | disclosed |
| US-8901134-B2 | Pyrazolo [3,4-D] pyrimidine derivatives useful to treat respiratory disorders | NOVARTIS AG (CH) | 2014-12-02 | — | — | US | disclosed |
| US-20140235632-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2014-08-21 | — | — | US | disclosed |
| US-20140051698-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
| EP-2026811-A1 | PYRAZOLO [3, 4-D]PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | Novartis AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| US-7488569-B2 | Negative resist composition, a method for forming a resist pattern thereof, and a method for fabricating a semiconductor device | FUJITSU LIMITED (JP) | 2009-02-10 | — | — | US | disclosed |
| WO-2007134828-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2007-11-29 | — | — | WO | disclosed |
| US-20060263723-A1 | Negative resist composition, a method for forming a resist pattern thereof, and a method for fabricating a semiconductor device | FUJITSU LIMITED (JP) | 2006-11-23 | — | — | US | disclosed |
| US-7122288-B2 | Negative resist composition, a method for forming a resist pattern thereof, and a method for fabricating a semiconductor device | FUJITSU LIMITED (JP) | 2006-10-17 | — | — | US | disclosed |
| US-20020177070-A1 | Negative resist composition, a method for forming a resist pattern thereof, and a method for fabricating a semiconductor device | FUJITSU LIMITED (JP) | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | NPC1 2237/4885TLR7 1301/4885TLR9 1750/4885 |
| US-20140051698-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | NPC1 2237/4885TLR7 1301/4885TLR9 1750/4885 |
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | NPC1 2237/4885TLR7 1301/4885TLR9 1750/4885 |
| US-20140235632-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | NPC1 2237/4885TLR7 1301/4885TLR9 1750/4885 |
| US-20180125849-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | NPC1 2237/4885TLR7 1301/4885TLR9 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.