Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265206 | 0.85 | TLR7 (0.38) | TLR7TLR9TLR8ESR1KMT2A | |
| SCHEMBL4231672 | 0.81 | IDO1 (0.42) | TLR7TLR9TLR8ESR1KMT2A | |
| SCHEMBL4223741 | 0.81 | NPC1 (0.46) | TLR7TLR9TLR8ESR1KMT2A | |
| SCHEMBL4219371 | 0.80 | ESR1 (0.57) | TLR7TLR9TLR8ESR1KMT2A | |
| SCHEMBL4227399 | 0.79 | TLR7 (0.41) | TLR7TLR9TLR8ESR1KMT2A | |
| SCHEMBL4262447 | 0.78 | TLR7 (0.39) | TLR7TLR9TLR8ESR1CDK4 | |
| SCHEMBL4228641 | 0.76 | TLR7 (0.45) | TLR7TLR9TLR8ADORA2AADORA1 | |
| SCHEMBL4216196 | 0.76 | TLR7 (0.59) | TLR7TLR9TLR8ESR1KDR | |
| SCHEMBL4229742 | 0.75 | TLR7 (0.41) | TLR7TLR9TLR8ESR1ADORA2A | |
| SCHEMBL4224031 | 0.75 | TLR7 (0.41) | TLR7TLR9TLR8JAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.