Sugi Predict

Sugi Predict / Compounds / SCHEMBL422503

SCHEMBL422503

SCHEMBL422503

CCOC(=O)c1cc(-c2cccc(C#N)c2)c(-c2cc(F)cc(Cl)c2)s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 1/20 0.48
▸ FNTA P49354 3/20 0.46
▸ FNTB P49356 3/20 0.46
▸ CNR2 P34972 1/20 0.43
▸ TLR8 Q9NR97 1/20 0.41
▸ TLR7 Q9NYK1 1/20 0.41
▸ PTGDR2 Q9Y5Y4 2/20 0.40
▸ ALDH1A1 P00352 3/20 0.39
▸ HPGD P15428 3/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ TDP1 Q9NUW8 2/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ TRPM8 Q7Z2W7 2/20 0.38
▸ SETD7 Q8WTS6 1/20 0.38
▸ HRH2 P25021 1/20 0.37
▸ HRH1 P35367 1/20 0.37
▸ GAA P10253 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL426748 0.89 FNTA (0.47) MAPK14FNTAFNTBCNR2TLR8
SCHEMBL423848 0.86 MAPK14 (0.52) MAPK14FNTAFNTBCNR2PTGDR2
SCHEMBL2505963 0.85 FNTA (0.41) FNTAFNTBCNR2TLR8TLR7
SCHEMBL419608 0.85 PTGDR2 (0.43) MAPK14FNTAFNTBPTGDR2MAPT
SCHEMBL420399 0.85 MAPK14 (0.51) MAPK14FNTAFNTBALDH1A1HPGD
SCHEMBL421904 0.82 MAPK14 (0.56) MAPK14ALDH1A1HPGDKDM4ETDP1
SCHEMBL10109873 0.79 TRPM8 (0.54) MAPK14ALDH1A1HPGDKDM4ETDP1
SCHEMBL419840 0.77 FNTA (0.42) FNTAFNTBCNR2TLR8TLR7
SCHEMBL426459 0.75 MAPK14 (0.39) MAPK14PTGDR2MAPT
SCHEMBL421731 0.75 MAPK14 (0.46) MAPK14CNR2ALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546438-B2 Substituted (thiophenyl-carbonyl)imidazolidinones, and use thereof BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2013-10-01 — — US disclosed
US-8546438-B2 Substituted (thiophenyl-carbonyl)imidazolidinones, and use thereof BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2013-10-01 — — US disclosed
US-8546438-B2 Substituted (thiophenyl-carbonyl)imidazolidinones, and use thereof BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2013-10-01 — — US disclosed
EP-2376482-B1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO KG (DE) 2013-03-06 — — EP disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
WO-2010075962-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF TPMT, MAVS, EIF2AK2 MAPK14 2294/4885FNTA 2687/4885FNTB 2776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.