Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050823 | 0.94 | MAPT (0.46) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL3620446 | 0.78 | MAPT (0.39) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL21670228 | 0.78 | MAPT (0.39) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL2839539 | 0.77 | MAPT (0.38) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL28278368 | 0.73 | MAPT (0.45) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL29646187 | 0.67 | — | — | |
| SCHEMBL21955432 | 0.67 | — | — | |
| SCHEMBL1709532 | 0.67 | CYP3A4 (0.45) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL12919608 | 0.67 | NPSR1 (0.41) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 | |
| SCHEMBL3666455 | 0.67 | NPSR1 (0.37) | MAPTNPSR1ALDH1A1L3MBTL1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049548-A1 | FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS | UCB Pharma, S.A. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012010-A1 | FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS | UCB PHARMA, S.A. (BE) | 2008-01-31 | — | — | WO | disclosed |