Rotenone

Rotenone

SCHEMBL42253

C=C(C)[C@H]1Cc2c(ccc3c2O[C@@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 11/20 1.00
MAPT P10636 8/20 1.00
SMN1; SMN2 Q16637 8/20 1.00
ALDH1A1 P00352 5/20 1.00
KDM4E B2RXH2 5/20 1.00
TDP1 Q9NUW8 5/20 1.00
CYP2C19 P33261 4/20 1.00
LMNA P02545 4/20 1.00
MAPK1 P28482 4/20 1.00
TP53 P04637 4/20 1.00
USP2 O75604 4/20 1.00
TSHR P16473 3/20 1.00
MT-ND4 P03905 3/20 1.00
CYP2C9 P11712 2/20 1.00
NPC1 O15118 2/20 1.00
RAB9A P51151 2/20 1.00
CYP1A2 P05177 2/20 1.00
HPGD P15428 2/20 1.00
GMNN O75496 1/20 1.00
ABCB11 O95342 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rotenone SCHEMBL20152380 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL29388856 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL13845713 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL9815546 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL13926662 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL29351552 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL19019920 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL5490007 0.99 CYP3A4 (0.98) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL7142434 0.97 CYP3A4 (0.95) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL8386940 0.96 CYP3A4 (0.93) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 35336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137082-A1 FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL SYNGENTA CROP PROTECTION AG (CH) 2026-05-21 US claimed
CN-122005800-A Application of CH25H in treating intestinal cancer 中山大学附属第六医院 2026-05-12 CN claimed
EP-4737584-A1 METHOD FOR EVALUATING INTERCELLULAR INTERACTION OF NEUROINFLAMMATION FUJIFILM Corporation (JP) 2026-05-06 EP claimed
EP-4734762-A1 BAIT COMPOSITIONS FMC Corporation (US) 2026-05-06 EP claimed
US-20260117276-A1 Frozen Biofluids Mitochondrial Bioenergetics Function Assessment Method for Traumatic Brain Injury and Polytrauma The Government of the United States, as represented by the Director of the Defense Health Agency (US) 2026-04-30 US claimed
US-20260118345-A1 METHOD OF EVALUATING INTERCELLULAR INTERACTIONS IN NEUROINFLAMMATION FUJIFILM CORPORATION (JP) 2026-04-30 US claimed
EP-4719059-A1 INCREASED PALATABILITY OF INSECTICIDAL INSECT BAITS Bio Logic Crop Science, S.L. (ES) 2026-04-08 EP claimed
US-20260083129-A1 PYRAZOLE AMIDE INSECTICIDES FMC CORP (US) 2026-03-26 US claimed
US-20260083130-A1 NOVEL SULFONATE BENZAMIDE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS FMC CORP (US) 2026-03-26 US claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
EP-0186807-B1 ANTHRACYCLINE DERIVATIVES, THEIR MICROBIOLOGICAL PREPARATION AND THEIR USE AS MEDICINES HOECHST AKTIENGESELLSCHAFT (DE) 1989-08-16 EP claimed
US-4756118-A Method and apparatus for the destruction of imported fire ants of the genus Solenopsis EVANS II CHARLES W (US) 1988-07-12 US claimed
US-4698222-A Extraction of insecticides from plants SAPHYR S.A.R.L. (FR) 1987-10-06 US claimed
EP-0224457-A1 Micro-capsules Biogram AB (SE) 1987-06-03 EP claimed
WO-1987002582-A1 MICRO-CAPSULES BIOGRAM AB (SE) 1987-05-07 WO claimed
EP-0186807-A2 Anthracycline derivatives, their microbiological preparation and their use as medicines HOECHST AKTIENGESELLSCHAFT (DE) 1986-07-09 EP claimed
EP-0162545-A2 Enhanced bioconversion processes BETZ EUROPE, INC. (US) 1985-11-27 EP claimed
US-4195080-A Insecticidal use of orange juice essence oil DUFF, TEODORO E. (PA) 1980-03-25 US claimed
US-4160336-A Method for treating fireants QUERY GRADY W 1979-07-10 US claimed
US-4034080-A 4-METHYL-3-HEPTANOL, 2,4-DIMETHYL-5-ETHYL-6,8-DIOXA-BICYCLO(3.2.1)OCTANE, ALPHA-CUBEBENE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1977-07-05 US claimed