Rotenone

Rotenone

SCHEMBL19019920

C=C(C)[C@H]1Cc2c(ccc3c2O[C@@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1.C=C(C)[C@H]1Cc2c(ccc3c2O[C@@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 11/20 1.00
MAPT P10636 8/20 1.00
SMN1; SMN2 Q16637 8/20 1.00
ALDH1A1 P00352 5/20 1.00
KDM4E B2RXH2 5/20 1.00
TDP1 Q9NUW8 5/20 1.00
CYP2C19 P33261 4/20 1.00
LMNA P02545 4/20 1.00
MAPK1 P28482 4/20 1.00
TP53 P04637 4/20 1.00
USP2 O75604 4/20 1.00
TSHR P16473 3/20 1.00
MT-ND4 P03905 3/20 1.00
CYP2C9 P11712 2/20 1.00
NPC1 O15118 2/20 1.00
RAB9A P51151 2/20 1.00
CYP1A2 P05177 2/20 1.00
HPGD P15428 2/20 1.00
GMNN O75496 1/20 1.00
ABCB11 O95342 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rotenone SCHEMBL20152380 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL29388856 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL13845713 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL9815546 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL13926662 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL42253 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL29351552 1.00 CYP3A4 (1.00) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL5490007 0.99 CYP3A4 (0.98) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL7142434 0.97 CYP3A4 (0.95) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E
Rotenone SCHEMBL8386940 0.96 CYP3A4 (0.93) CYP3A4MAPTSMN1; SMN2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200288719-A1 COMPOSITION FOR AQUATIC PEST CONTROL OMYA INTERNATIONAL AG (CH) 2020-09-17 US claimed
EP-3393239-A1 COMPOSITION FOR AQUATIC PEST CONTROL Omya International AG (CH) 2018-10-31 EP claimed
CN-108601341-A Composition for preventing aquatic pests OMYA国际股份公司 2018-09-28 CN claimed
WO-2017109162-A1 COMPOSITION FOR AQUATIC PEST CONTROL OMYA INTERNATIONAL AG (CH) 2017-06-29 WO claimed
EP-3183965-A1 COMPOSITION FOR AQUATIC PEST CONTROL Omya International AG (CH) 2017-06-28 EP claimed
EP-3393239-B1 USE OF A COMPOSITION FOR AQUATIC PEST CONTROL OMYA INT AG (CH) 2023-10-18 EP disclosed
US-20210299118-A1 Coordinated Metabolic Reprogramming in Response to Productive Viral Infections ST. JUDE CHILDREN'S RESEARCH HOSPITAL 2021-09-30 US disclosed
US-11083725-B2 Coordinated metabolic reprogramming in response to productive viral infections ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2021-08-10 US disclosed
US-20200288719-A1 COMPOSITION FOR AQUATIC PEST CONTROL OMYA INTERNATIONAL AG (CH) 2020-09-17 US disclosed
EP-3393239-A1 COMPOSITION FOR AQUATIC PEST CONTROL Omya International AG (CH) 2018-10-31 EP disclosed
CN-108601341-A Composition for preventing aquatic pests OMYA国际股份公司 2018-09-28 CN disclosed
US-20170304293-A1 COORDINATED METABOLIC REPROGRAMMING IN RESPONSE TO PRODUCTIVE VIRAL INFECTIONS ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2017-10-26 US disclosed
WO-2017109162-A1 COMPOSITION FOR AQUATIC PEST CONTROL OMYA INTERNATIONAL AG (CH) 2017-06-29 WO disclosed
EP-3183965-A1 COMPOSITION FOR AQUATIC PEST CONTROL Omya International AG (CH) 2017-06-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200288719-A1 COMPOSITION FOR AQUATIC PEST CONTROL CA2, MT-CO2, CA3 CYP3A4 1035/4885MAPT 2048/4885SMN1; SMN2 2962/4885
US-20210299118-A1 Coordinated Metabolic Reprogramming in Response to Productive Viral Infections MAVS, ATF4, PC CYP3A4 2786/4885MAPT 2780/4885SMN1; SMN2 3404/4885
US-20170304293-A1 COORDINATED METABOLIC REPROGRAMMING IN RESPONSE TO PRODUCTIVE VIRAL INFECTIONS MAVS, ATF4, PC CYP3A4 2786/4885MAPT 2780/4885SMN1; SMN2 3404/4885
US-11083725-B2 Coordinated metabolic reprogramming in response to productive viral infections MAVS, ATF4, PC CYP3A4 2786/4885MAPT 2780/4885SMN1; SMN2 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.