Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ATF4 | P18848 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4226008 | 1.00 | FPR2 (0.45) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4226126 | 0.99 | FPR2 (0.44) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4217635 | 0.89 | SLC6A2 (0.39) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4217638 | 0.89 | SLC6A2 (0.39) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4216475 | 0.87 | SLC6A2 (0.38) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4215952 | 0.87 | SLC6A2 (0.53) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4213275 | 0.87 | SLC6A2 (0.53) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4209491 | 0.85 | SLC6A2 (0.51) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1177444 | 0.83 | SLC6A3 (0.55) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1177443 | 0.83 | SLC6A3 (0.55) | FPR2PROKR1SLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638532-B2 | 3-aryloxy-8-aza-bicyclo[3.2.1]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2009-12-29 | — | — | US | claimed |
| US-20090030035-A1 | 3-Aryloxy-8-aza-bicyclo[3.2.1]]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2009-01-29 | — | — | US | claimed |
| EP-1896468-A1 | 3 -ARYLOXY- 8 -AZA-BICYCLO [3.2.1.] OCT- 6- ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2008-03-12 | — | — | EP | claimed |
| WO-2006131525-A1 | 3 -ARYLOXY- 8 -AZA-BICYCLO [3.2.1.] OCT- 6- ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2006-12-14 | — | — | WO | claimed |
| US-7638532-B2 | 3-aryloxy-8-aza-bicyclo[3.2.1]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2009-12-29 | — | — | US | disclosed |
| US-20090030035-A1 | 3-Aryloxy-8-aza-bicyclo[3.2.1]]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2009-01-29 | — | — | US | disclosed |
| EP-1896468-A1 | 3 -ARYLOXY- 8 -AZA-BICYCLO [3.2.1.] OCT- 6- ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006131525-A1 | 3 -ARYLOXY- 8 -AZA-BICYCLO [3.2.1.] OCT- 6- ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030035-A1 | 3-Aryloxy-8-aza-bicyclo[3.2.1]]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | SLC18A2, SLC6A2, SLC18A3 | FPR2 3266/4885PROKR1 3908/4885SLC6A2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.