Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 4/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | HAT1 | O14929 | 2/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841271 | 1.00 | GPR139 (0.40) | GPR139TEKKDREPHB4BRD4 | |
| SCHEMBL1841473 | 0.93 | GPR139 (0.40) | GPR139TEKKDREPHB4MET | |
| SCHEMBL4218121 | 0.93 | GPR139 (0.40) | GPR139TEKKDREPHB4MET | |
| SCHEMBL1843451 | 0.92 | GPR139 (0.46) | GPR139MMP1MMP2MMP3MMP9 | |
| SCHEMBL1844124 | 0.91 | MMP2 (0.42) | GPR139METMMP1MMP2MMP3 | |
| SCHEMBL1843415 | 0.90 | GPR139 (0.39) | GPR139BRD4MMP1MMP2MMP3 | |
| SCHEMBL4927195 | 0.90 | GPR139 (0.45) | GPR139MMP1MMP2MMP3MMP9 | |
| SCHEMBL1843081 | 0.89 | GPR139 (0.47) | GPR139MMP1MMP2MMP3MMP9 | |
| SCHEMBL4204897 | 0.89 | GPR139 (0.47) | GPR139MMP1MMP2MMP3MMP9 | |
| SCHEMBL4204895 | 0.89 | GPR139 (0.47) | GPR139MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074093-A2 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008023336-A2 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2008-02-28 | — | — | WO | disclosed |