Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 18/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224211 | 0.85 | SSTR5 (0.36) | SSTR5HRH1HTR2BALDH1A1 | |
| SCHEMBL4227031 | 0.83 | SSTR5 (0.44) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4237355 | 0.82 | SSTR5 (0.49) | SSTR5HRH1HTR2BSSTR1UTS2R | |
| SCHEMBL4226457 | 0.82 | SSTR5 (0.31) | SSTR5 | |
| SCHEMBL3771895 | 0.82 | SSTR5 (0.57) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4234146 | 0.82 | SSTR5 (0.39) | SSTR5HRH1HTR2BKCNH2 | |
| SCHEMBL4227035 | 0.79 | SSTR5 (0.40) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4234809 | 0.78 | SSTR5 (0.44) | SSTR5HRH1HTR2BSSTR1UTS2R | |
| SCHEMBL4237976 | 0.75 | SLC2A1 (0.46) | SSTR5HRH1HTR2BSSTR1 | |
| SCHEMBL4958186 | 0.74 | SSTR5 (0.51) | SSTR5HRH1HTR2BSSTR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |