SCHEMBL4227552

SCHEMBL4227552

[CH2]C(C)[C@H](C(=O)NO)N(Cc1cccnc1)S(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.73

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 17/20 0.73
MMP2 P08253 11/20 0.73
MMP13 P45452 13/20 0.69
MMP8 P22894 7/20 0.69
ADAMTS4 O75173 1/20 0.55
MMP1 P03956 5/20 0.54
ADAM17 P78536 4/20 0.54
MMP3 P08254 1/20 0.53
BMP1 P13497 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29350980 0.92 MMP9 (0.80) MMP9MMP2MMP13MMP8ADAMTS4
SCHEMBL3468444 0.92 MMP9 (0.80) MMP9MMP2MMP13MMP8ADAMTS4
SCHEMBL3468445 0.92 MMP9 (0.80) MMP9MMP2MMP13MMP8ADAMTS4
SCHEMBL13253256 0.92 MMP9 (0.80) MMP9MMP2MMP13MMP8ADAMTS4
Hydrochloric Acid SCHEMBL7351872 0.91 MMP9 (0.78) MMP9MMP2MMP13MMP8ADAMTS4
Hydrochloric Acid SCHEMBL3158786 0.91 MMP9 (0.78) MMP9MMP2MMP13MMP8ADAMTS4
Hydrochloric Acid SCHEMBL3158778 0.91 MMP9 (0.78) MMP9MMP2MMP13MMP8ADAMTS4
SCHEMBL13643228 0.88 MMP9 (0.75) MMP9MMP2MMP13MMP8MMP1
SCHEMBL13643229 0.88 MMP9 (0.75) MMP9MMP2MMP13MMP8MMP1
Hydrochloric Acid SCHEMBL7347881 0.87 MMP9 (0.66) MMP9MMP2MMP13MMP8ADAMTS4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8309788-B2 Protease inhibitors in absorbent articles THE PROCTER AND GAMBLE COMPANY (US) 2012-11-13 US claimed
US-20090131890-A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES ROURKE FRANCIS JAMES 2009-05-21 US claimed
EP-1061963-B1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES PROCTER & GAMBLE (US) 2003-05-07 EP claimed
JP-2002505917-A 2002-02-26 JP claimed
EP-1061963-A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES THE PROCTER & GAMBLE COMPANY (US) 2000-12-27 EP claimed
WO-1999045974-A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES THE PROCTER & GAMBLE COMPANY (US) 1999-09-16 WO claimed
US-10265434-B2 Absorbent articles comprising glyceride copolymers THE PROCTER & GAMBLE COMPANY (US) 2019-04-23 US disclosed
US-20180161474-A1 ABSORBENT ARTICLES COMPRISING GLYCERIDE COPOLYMERS THE PROCTER & GAMBLE COMPANY 2018-06-14 US disclosed
WO-2018013151-A1 ABSORBENT ARTICLES COMPRISING METATHESIZED UNSATURATED POLYOL ESTERS THE PROCTER & GAMBLE COMPANY (US) 2018-01-18 WO disclosed
US-20180008484-A1 ABSORBENT ARTICLES COMPRISING METATHESIZED UNSATURATED POLYOL ESTERS THE PROCTER & GAMBLE COMPANY 2018-01-11 US disclosed
US-8309788-B2 Protease inhibitors in absorbent articles THE PROCTER AND GAMBLE COMPANY (US) 2012-11-13 US disclosed
US-8262634-B1 Absorbent article having barrier sheet against the migration of the skin care composition THE PROCTER & GAMBLE COMPANY (US) 2012-09-11 US disclosed
EP-1178846-B1 ABSORBENT ARTICLE WITH SKIN CARE COMPOSITION PROCTER & GAMBLE (US) 2009-09-02 EP disclosed
EP-1061963-A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES THE PROCTER & GAMBLE COMPANY (US) 2000-12-27 EP disclosed
WO-2000069482-A1 ABSORBENT ARTICLE WITH SKIN CARE COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2000-11-23 WO disclosed
WO-2000069483-A1 ABSORBENT ARTICLE WITH SKIN CARE COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2000-11-23 WO disclosed
WO-2000069484-A1 ABSORBENT ARTICLE WITH SKIN CARE COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2000-11-23 WO disclosed
WO-2000069485-A1 ABSORBENT ARTICLE WITH SKIN CARE COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2000-11-23 WO disclosed
WO-1999045973-A1 DISPOSABLE ABSORBENT ARTICLE HAVING A SKIN CARE COMPOSITION CONTAINING AN ENZYME INHIBITOR THE PROCTER & GAMBLE COMPANY (US) 1999-09-16 WO disclosed
WO-1999045974-A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES THE PROCTER & GAMBLE COMPANY (US) 1999-09-16 WO disclosed