SCHEMBL4227993

SCHEMBL4227993

CC(C)c1cccc(CCC=O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 3/20 0.41
HDAC4 P56524 2/20 0.41
HDAC8 Q9BY41 2/20 0.41
KDM4E B2RXH2 2/20 0.41
MDM4 O15151 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
TP53 P04637 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
CA5A P35218 1/20 0.41
HTT P42858 1/20 0.41
MDM2 Q00987 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CA9 Q16790 1/20 0.41
HDAC2 Q92769 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31634534 1.00 TYR (0.41) TYRHDAC4HDAC8KDM4EMDM4
SCHEMBL6572567 0.90 HDAC4 (0.39) TYRHDAC4HDAC8KDM4EMDM4
SCHEMBL11198497 0.87 CYSLTR2 (0.42) TYRHDAC4HDAC8KDM4EMDM4
SCHEMBL8802769 0.83 CHRM2 (0.35) HDAC4HDAC8DAOCHRM2CHRM1
SCHEMBL453825 0.83 TYR (0.44) TYRHDAC4HDAC8KDM4EMDM4
SCHEMBL8145669 0.82 HDAC4 (0.36) HDAC4HDAC8ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL16167427 0.82 HDAC4 (0.37) TYRHDAC4HDAC8KDM4EMDM4
SCHEMBL8907481 0.81 CHRM2 (0.36) DAOCHRM2CHRM1CHRM3CYSLTR2
SCHEMBL19258592 0.80 MEN1 (0.43) CHRM2CHRM1CHRM3
SCHEMBL27298726 0.79 GABRA1 (0.37) CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009131692-A1 SUBSTRATES FOR DELIVERY OF PHYSIOLOGICALLY ACTIVE AGENTS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2009-10-29 WO claimed
WO-2009131692-A1 SUBSTRATES FOR DELIVERY OF PHYSIOLOGICALLY ACTIVE AGENTS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2009-10-29 WO disclosed
US-5677299-A VASOPRESSIN OR OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1997-10-14 US disclosed
US-5498609-A Benzoazepinyl compounds as oxytocin and vasopressin antagonists OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1996-03-12 US disclosed
EP-0612319-A1 BENZOHETEROCYCLIC COMPOUNDS AS OXYTOCIN AND VASOPRESSIN ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-08-31 EP disclosed
CN-1090576-A Benzoheterocyclic compounds OTSUKA PHARMA CO LTD (JP) 1994-08-10 CN disclosed
WO-1994004525-A1 BENZOHETEROCYCLIC COMPOUNDS AS OXYTOCIN AND VASOPRESSIN ANTAGONISTS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-03-03 WO disclosed