Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.67 |
| ▸ | DRD1 | P21728 | 4/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | HRH1 | P35367 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tripelennamine SCHEMBL17970 | 0.80 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL29600775 | 0.80 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL29363256 | 0.79 | KDM4E (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL1652325 | 0.79 | CHRM2 (0.97) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL98916 | 0.79 | KDM4E (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL2955098 | 0.79 | CHRM2 (0.54) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL15270438 | 0.75 | CHRM2 (0.89) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Pyrilamine SCHEMBL4075657 | 0.75 | LMNA (0.90) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Chloropyramine SCHEMBL13723581 | 0.73 | CYP2D6 (0.95) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL12667801 | 0.73 | LMNA (0.68) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124645-A1 | Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels | NEUROSEARCH A/S (DK) | 2009-05-14 | — | — | US | claimed |
| US-20090124645-A1 | Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels | NEUROSEARCH A/S (DK) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124645-A1 | Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels | KCNN2, KCNN1, KCNN3 | CHRM2 1704/4885ADRA2A 710/4885DRD1 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.